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Vetoryl For Dogs

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Vetoryl (trilostane) Capsules, 10mg, 30
Price: $63.24
Item #: 1016986 -
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Vetoryl (trilostane) Capsules, 120 mg, 30
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Vetoryl (trilostane) Capsules, 30 mg, 30
Price: $78.60
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Vetoryl (trilostane) Capsules, 60 mg, 30
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Vetoryl Canine Cushing's Disease Medications

Rating: based on 128 reviews

What is Vetoryl?

Vetoryl is a prescription medication manufactured by Dechra Veterinary Products used to treat Cushing's Disease (hyperadrenocorticism) in dogs. This disease is caused when your dog's body produces too much of the hormone cortisol. This overproduction of cortisol is usually caused by a tumor in the pituitary gland that overstimulates the adrenal glands or by a hormone-secreting gland.

The main ingredient in Vetoryl is trilostane, a drug that stops excess cortisol production in the adrenal glands. This is important because cortisol helps regulate many processes in your dog's body. Vetoryl is also first medication approved to treat pituitary-dependent and adrenal-dependent cases of Cushing's Disease in dogs. While Vetoryl Capsules won't Cushing's Disease, they can help control the symptoms (increased appetite, hair loss, a pot-bellied appearance, weakness, breathing problems, and more), and generally, dogs will see improvements in several weeks.


  • Effective treatment for the symptoms of Cushing's Disease in dogs
  • Generally causes fewer or less severe side effects than Mitotane
  • Helps dogs with adrenal-dependent or pituitary-dependent cases of Cushing's Disease
  • Helps control excess cortisol production
  • Improvements come in as little as several weeks

How Vetoryl for Dogs Works

Vetoryl works by controlling the production of cortisol by the adrenal glands. This helps dogs with hyperadrenocorticism, commonly known as Cushing's Disease. More specifically, trilostane, the active ingredient in Vetoryl, inhibits the conversion of pregnenolone to progesterone to block the production of glucocorticoids, sex hormones, and mineralocorticoids while steroid precursor levels increase.

Brand Name


Generic Name



Dechra Veterinary Products


Vetoryl is available in capsule form in four different strengths: 10 mg, 30 mg, 60 mg, and 120 mg.

Common Misspellings

Vectoryl, Vereryl, Vertoryl, Vetarol, Veterol, Veteroyl, Veteryl, Vetiryl, Vetoril, Vetoroyl, Vetotryl, Vetrosyl, Vetyrol, Vitoral, Vytoral, Vytoril

Warranty and Manufacturer Information

Dechra Veterinary Products

7015 College Blvd., Ste. 525, Overland Park, KS, 66211

Telephone: 913-327-0015

Toll-Free: 866-933-2472


Vetoryl NAC No.: 14590510

The above is provided for information purposes only and should not be used for the diagnosis or treatment of any condition. This information does not cover all possible variables, conditions, reactions, or risks relating to any topic, medication, or product and should not be considered complete. Certain products or medications may have risks and you should always consult your local veterinarian concerning the treatment of your pet. Any trademarks are the property of their respective owners.

How to Use Vetoryl


The starting dose for dogs is 1.0-3.0 mg/lb (2.2-6.7 mg/kg) of Vetoryl once a day based on your pet's weight and capsule size. Vetoryl should be given with food. The following table gives the starting doses, but be sure to follow your veterinarian's specific instructions.

Weight (lbs.) Weight (kg) Dosage
3.8-10 lbs. 1.7-4.5 kg 10 mg once daily
10-22 lbs. 4.5-20 kg 30 mg once daily
22-44 lbs. 10-20 kg 60 mg once daily
44-88 lbs. 20-40 kg 120 mg once daily
88-132 lbs. 40-60 kg 180 mg (1 x 120 mg & 1 x 60 mg) once daily

After about 10-14 days after starting Vetoryl, your veterinarian will re-examine your dog and conduct a 4-6 hour post-dosing ACTH stimulation test. They will then adjust your pet's dosage or leave it the same. In some cases, once daily dosing may not be enough to control clinical signs of Cushing's Disease for a full day. In these cases, your veterinarian will instruct you on how to administer twice daily dosing. Be sure to follow their specific instructions, because with Vetoryl, individual dose adjustments and monitoring are paramount.

Side Effects

The most common side effects of Vetoryl Capsules include: decreased appetite, vomiting, diarrhea, and weakness/lethargy. Rare and more serious side effects may be seen including bloody diarrhea, severe depression, collapse, hypoadrenocortical crisis, or other severe side effects that may result in death. If you believe your dog is having an adverse reaction to Vetoryl, stop administering it and seek immediate veterinary care.


Talk to your veterinarian if your pet has kidney or liver disease before giving them Vetoryl. Be sure to tell your veterinarian about any other medications or supplements your dog may be taking as certain products may interact and cause detrimental side effects.

ACE inhibitors should be used with caution with Vetoryl, as both drugs have aldosterone-lowering effects which may impair your pet's ability to maintain electrolyte levels and more. Potassium sparing diuretics should not be used with Vetoryl.

Do not administer Vetoryl to cats or other animals. Do not allow children to handle Vetoryl. Be sure to read all directions and precautionary statements before use.


Store Vetoryl in its original packaging and out of reach of children and animals. Store this product at controlled room temperature.

It is a violation of Federal Law to use this product in a manner inconsistent with its labeling.

What is Vetoryl and what does it do?

Vetoryl is a prescription medication that is used to control cortisol production in dogs in order to treat Cushing's Disease (hyperadrenocorticism). The main ingredient in Vetoryl, trilostane, inhibits the conversion of pregnenolone to progesterone to block the production of glucocorticoids, sex hormones, and mineralocorticoids while steroid precursor levels increase. While Vetoryl cannot cure Cushing's Disease, it is an important part of the long-term management of the symptoms.

Why would my dog need Vetoryl?

Your veterinarian might recommend putting your dog on Vetoryl if they have pituitary-dependent or adrenal-dependent Cushing's Disease.

What else should I discuss with my veterinarian while considering Vetoryl?

Vetoryl and Cushing's Disease require long-term monitoring and frequent tests. Be sure to ask what signs your dog should show while on Vetoryl and when to contact your veterinarian. Also, find out what kinds of tests and exams will be necessary to monitor your pet's condition. You should also use this time to discuss the possible risks associated with Vetoryl and tell your veterinarian about any other medications or over-the-counter supplements your pet may be taking. Also inform your veterinarian if your pet has any kidney or liver diseases.

What are the side effects?

The most common side effects of Vetoryl Capsules include: decreased appetite, vomiting, diarrhea, and weakness/lethargy. The following serious adverse effects are more rare: depression, bloody diarrhea, collapse, hypoadrenocortical crisis, adrenal necrosis/rupture, or other severe reactions that may lead to death.

What should I do if a side effect occurs?

If you observe an adverse reaction to Vetoryl in your dog, discontinue use and contact your veterinarian immediately.

What should I do if I miss a dose?

If you miss giving your dog a dose, give it as soon as you remember. If it is almost time for the next dose, skipped the missed one and get back on the regular Vetoryl dosing schedule. Do not give two doses at once.

How far apart should I give Vetoryl?

Vetoryl is designed to be given once daily. However, some dogs may not respond to just once a day dosing. If the clinical signs of Cushing's Disease are not controlled for a full day, discuss with your veterinarian if they think administering Vetoryl twice daily is necessary.

Can I open the Vetoryl capsules?

Vetoryl should be administered whole and with food. Do not break the capsules open. If your dog does not like taking the medication, try hiding the capsules in Greenies Pill Pockets or a similar product.

Does Vetoryl work for life?

Vetoryl is not a cure for Cushing's Disease, but it can help control the various symptoms. In most cases, treatment with Vetoryl will need to continue for life. If use of the medication is discontinued, the signs of hyperadrenocorticism will reappear.

Trilostane vs Vetoryl

Trilostane is the name of the drug in Vetoryl. However, there is no generic alternative to Vetoryl.

Will Vetoryl affect my dog's diabetes?

Vetoryl is not used to treat diabetes or control blood sugar levels. If your dog has diabetes and Cushing's Disease you should be in close contact with your veterinarian to make sure your pet gets the best treatment that's right for them.

Who manufactures Vetoryl?

Vetoryl is manufactured by Dechra Veterinary Products.

What do I do if my dog on Vetoryl has intermittent urinary tract infections?

During a US field study, urinary tract infections were recorded in some of the dogs taking Vetoryl. If your dog has intermittent UTIs while on Vetoryl, consult with your veterinarian.

Can I give my dog Vetoryl and Selegiline?

You should discuss this with your veterinarian. Talk to them about any other medications or over-the-counter supplements your pet may be taking. Do not adjust doses or begin administering new medications to your pet without their approval.

Can a pregnant woman administer Vetoryl?

The manufacturer's label and packaging materials state that women who are pregnant or trying to conceive should not handle Vetoryl capsules.

Why did my veterinarian recommended Lysodren instead of Vetoryl?

Both Lysodren and Vetoryl are used to treat Cushing's Disease in dogs, but they work differently. Which one will work best for your pet depends on the type of Cushing's Disease they have, its severity, and many other factors. You should ask your veterinarian why they may have chosen one treatment option over another.

Can you liquify Vetoryl?

If you are having trouble getting your dog to take the Vetoryl capsules, try hiding them inside a Greenies Pill Pocket or other similar product. If that does not work, consult with your veterinarian.

Learn more about Vetoryl (Trilostane) for Dogs

Visit these additional resources to learn more about how Vetoryl can help dogs with Cushing's Disease.