My cat has Interstitial Cystitis. This was recommended by our Veterinarian. I got a 4 oz. dropper bottle, poured some Duralactin in it, then added a dab of water -- probably less than 1/4 teaspoon, shook it up well, then give him three droppersful each morning. For the first time in several years, he is no longer leaking urine when he sleeps, and is much more comfortable. Comfortable enough to play with the other cats! I also give him Cosequin and two herbal remedies for bladder treatment. He's very good about taking all of them. About two weeks ago, he told me he didn't need it morning and night -- tried to hide under the bed in the evening. Animals know a lot about what they need and what they don't. So, now I've been giving him all his medicines in the morning only and we're both happy!