We have a 13 year old Bichon who was starting to "get lost" in the house and barking at lint. We consulted his veterinarian, who said this supplement was untested, but it couldn't hurt. He seemed to get better, but we didn't see any big changes. After 2 bottles, we ran out. Within 2 weeks, he started barking at nothing again and was very confused and agitated. We quickly ordered more and within 1 week of restarting, he calmed down and was much better. We will definitely continue giving this to him and we think it is very much beneficial.