My 60 lb. lab is hypersensitive to sensory stimulus of any kind. Sight, sound, smell, touch...a very sensitive nervous system that seems always on hyper-alert. I think she would make an incredible working dog - search and rescue or being by a hunter/rancher/farmer's side 12 hours a day in the field. Sadly, her life requires that she "lay about" a chunk of every day (like most dogs!). Although she gets at least 2 hours of running, jumping, smelling, retrieving activity daily, and short play and training times in between, I have used Acepromazine to help her manage the times when she is hyper-aroused but I am not able to give her enough physical activity to tire her out (along with lots of behavioral training and touch therapy to calm her energy system). I really like that this medication is manufactured so that a 25 mg tablet can be broken into as many as 4 pieces. This way I can give her only enough to take the edge off and help her to calm given the situation. I work from home most of the time, but if I have to be gone for several hours during the day or evening, I give her more - a half tablet (she also has some separation anxiety), a quarter tablet at times when I am around but she is having trouble calming. I use it a few times per week, but because I can lower the dose whenever possible, I worry much less about her becoming dependent or over-medicating. I also use a supplement called L-theanine (with her vet's blessing). The brand I have found most effective is made by Enzymatic Therapy and is made with Suntheanine L-theanine (Amazon, Swanson). It is an amino acid that calms the brain/nervous system by promoting more alpha wave activity.