Vetoryl helps control symptoms of Cushing's
Disease within several weeks of treatment. Untreated, Cushing's Disease
can cause many symptoms, depending on the organs affected. Most commonly,
the disease causes hair loss, increased appetite, a pot-bellied appearance,
increased thirst and urination, thinning skin, fragile blood vessels,
weakness, panting, abnormal walking, blood clots, and breathing problems.
Cushing's Disease is caused by the overproduction of cortisol, an adrenal
Benefits of Vetoryl:
- Effective treatment for
the symptoms of Cushing's Disease in dogs
- Causes fewer and less severe
side effects than Mitotane
- Effective for both adrenal-dependent
and pituitary-dependent cases of Cushing's Disease
- Helps control excess cortisol
- Improvement seen in as little as several weeks
For Use In: Dogs weighing
at least 3.8 lbs.
This product is intended only for dogs.
Do not give to cats or other animals. Keep out of reach of children. Do not
allow children to administer Vetoryl. Read directions and precautionary
statements before use.
- The starting dose of Vetoryl
for the treatment of hyperadrenocorticism in dogs is 1.0-3.0 mg/lb given
once per day based on capsule size and body weight.
- Administer this product
with food. Absorption of Vetoryl is improved when the medication is
offered with food.
- Conduct and ACTH stimulation
test every 10 to 14 days following dose alteration. Administer Vetoryl
once daily unless otherwise instructed. Switch to twice daily dosing
gradually and only under veterinary supervision.
- Give a missed dose as soon
as possible. If it is nearly time for the next dose, skip the missed
dose and continue with your regular dosing schedule. Do not administer
two doses of this product at once.
- Immediately stop therapy
and consult your veterinarian if adverse reactions occur.
After approximately 10-14 days at this
dose, re-examine the dog and conduct a 4-6 hour post-dosing ACTH stimulation
test. If physical examination is acceptable, take action according to
Frequency of Use:
Vetoryl requires long-term monitoring.
Once an optimum dose is reached, re-examine the dog at 30 days and again
at 90 days. Re-examine every 3 months, including a physical examination,
medical history, and ACTH stimulation test.
Store in original container and out
of reach of children and animals.
Store this product at controlled room
It is a violation of Federal Law
to use this product in a manner inconsistent with its labeling.
Trilostane, the active ingredient in
Vetoryl, inhibits the conversion of pregnenolone to progesterone to
block the production of glucocorticoids, sex hormones, and mineralocorticoids
while steroid precursor levels increase.
Active ingredients: Trilostane
Keep this product out of reach of children
Vetoryl is intended for use in dogs
CAUTION: Do not give Vetoryl
to dogs that have shown a hypersensitivity to trilostane. Do not use
this medication in animals with renal insufficiency or primary hepatic
This medication is not for use in pregnant
dogs. Studies in laboratory animals show a risk of teratogenic effects
and pregnancy loss.
Vetoryl may cause hypoadrenocorticism
at any dose. It may take several months for adrenal function to return
to normal. Some dogs may never regain proper adrenal function.
A small number of dogs may develop
a condition called corticosteroid withdrawal syndrome within 10 days
of beginning treatment with Vetoryl. Signs of this syndrome include
lethargy, anorexia, weakness, and weight loss. Seek veterinary attention
if these signs develop.
It is not know if Vetoryl is safe for
use in lactating dogs or in males intended for breeding.
Adverse reactions may include vomiting,
diarrhea, reduced appetite, lethargy, weakness, depression, hemorrhagic
diarrhea, hypoadrenocortical crisis, adrenal necrosis/rupture, collapse,
and death. Immediately contact your veterinarian at the first sign of
For a copy of the Material Safety
Data Sheet (MSDS), or to report adverse reactions, call Dechra Veterinary
Products at (866) 933-2472.
Treat overdose with corticosteroids,
mineralocorticoids, and intravenous fluids.
Use ACE inhibitors cautiously in animals
being treated with Vetoryl. Both medications lower aldosterone, potentially
impairing the dog's ability to maintain normal levels of electrolytes,
blood volume, and renal perfusion. Do not use Vetoryl with potassium
sparing diuretics. Doing so increases the risk of hyperkalemia.
If Swallowed: Seek medical attention
immediately and bring the product label and container with you when
If on Skin: Wash hands thoroughly
using soap and clean water. This medication is associated with early
pregnancy loss and teratogenic effects and should not be handled by
pregnant persons or those trying to conceive.
Warranty and Manufacturer Information:
NADA 141-291, APPROVED BY FDA.
Distributed by: Dechra Veterinary Products,
7015 College Boulevard, Suite 525, Overland Park, KS 66211
VETORYL is a trademark of Dechra Ltd
© 2009, Dechra Ltd.
NAC No.: 12920131