100% Satisfaction Guarantee!
(800) 710-9770 | 9:30 - 7 est

Item# 1018525
Availability: In Stock
Usually ships In 1-3 Business Days

Was: $67.31
Retail: $92.99
Sale: $63.94
Save: $29.05 (31.2%)
  • Weekend Discount

Save 5% on every Autoship item!
Please select how often you would like your order placed
*please note: PayPal does not work with autoship


Quick Overview
  • No known side effects for your pet
  • Natural stress release supplement for dogs


Natural stress relief supplements for dogs

Zylkene 425 mg, 30 Capsules helps large and very large dogs cope with unusual and stressful situations as well as changes in their everyday lives. This nutritional supplement contains the milk protein casein, which has been shown to promote relaxation without sedating your pet. Because this is a nutritional supplement, it does not sedate your pet and is not known to have side effects.

Use Zylkene to help stop excessive vocalization, inappropriate urination and defecation, licking, and other behavioral signs of anxiety in pets. Ease your dog's stress and add more joy to their lives.


Zylkene Capsules can be fed directly or opened and the powder mixed in with your pet's food or a treat. Ideally start Zylkene a few days before fireworks, a veterinary or grooming visit, or a kennel stay. For long-term stressful situations, the manufacturer recommends Zylkene be given for a minimum of 1-2 months or longer if necessary. Always consult your veterinarian before starting your pet on any new supplement or medication.

Pets Dosage
Dogs 33-65 lbs. 1 capsule daily
Dogs 66-132 lbs. 2 capsules daily

Zylkene 425 mg, 30 Capsules Customer Reviews


Overall Customer Rating of 1 Reviews:

Helped My Dog

My 8 year old mixed breed has issues with gun fire in the woods and thunder. She had a fight with our 7 year old Coon Dog. She was out of sorts because we had a friend visiting with a smaller dog, staying with us for several weeks and it wanted a lot of attention. I took her to the vet for her annual and told her of the dog fight. She prescribed Zylkene and within a couple doses our house guest noticed a change in her demeanor.

Frequently Bought Together

Zylkene 225 mg, 30 Capsules

Zylkene 225 mg, 30 Capsules

In Stock
Retail: $65.99

Sale: $44.59 Save: $21.40

Chlorpheniramine Maleate 4 mg, 1000 Tablets

Chlorpheniramine Maleate 4 mg, 1000 Tablets

In Stock
Retail: $15.99

Sale: $10.91 Save: $5.08

Busy Buddy Kibble Nibble Food and Treat Activity Ball

Busy Buddy Kibble Nibble Food and Treat Activity Ball

Back Order
Retail: $32.99

Price: $16.20 Save: $16.79

Customers Who Bought This Item Also Bought

Lixotinic, Gallon

Lixotinic, Gallon

In Stock
Retail: $209.99

Price: $151.70 Save: $58.29

This information is for general reference only and should not be used for the diagnosis or treatment of any condition of your pet. Because is intended as a general reference, this information may not include all possible uses, precautions, directions, reactions (including allergic), drug interactions, or withdrawal times. Always consult your local veterinarian and have your pet examined for any advice concerning the diagnosis and treatment of your pet, including which products and doses are most appropriate. Any trademarks are the property of their respective owners. VetDepot is not a pharmacy. All prescription products are dispensed by our Pharmacy Partner.

Customer ServiceFree Shipping

The VetDepot Difference