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Advantage II kills lice and fleas for 4 weeks after applying. So far, none of my dogs have experienced any side effects and all have remained flea-free (3.5 weeks). I've come to order some more as I have 3 dogs and a 4-pack does not last me long. Based on what I saw online, VetDepot is the cheapest source for this flea control product.
I am very happy with the product. I have found it to be safe and effective. I used to have a farm and used the main ingredient on my farm animals numerous times. I was very glad when Advantage II was introduced. Also vet depots quick check out and delivery is exceptional.
We had a very bad flea problem two wks and they are almost completly gone. Leaves back a little greasy but disappears over 24 hrs or so. No bad reaction will be using again.