Percorten was a literal life saver for my dog, along with of course quick and decisive action by my vet. My Newfoundland had been showing some signs of lethargy and loss of appetite but I attributed it to his recent ACL surgery. His condition quickly deteriorated and I took him into the vet and they gave him some IV fluids and sent him home. When I woke the next day, my Newf was on the ground panting heavily and could not get up under his own power. He literally collapsed when he tried to get up. I slung a harness under his back legs to try to help him and he still could not get up. I quickly grabbed him under his belly and bear-dragged him out to my car (he's a Newf, not easy to carry) and got him into the vet ASAP. They quickly got him on IV and started running tests and diagnosed him with Addison's disease, or adrenal gland failure. Thank goodness they diagnosed this quickly as they said he was in shock and would have most likely died if he had not received immediate attention. Through IV fluids, and then a daily/monthly maintenance of Percorten with a small dose of Prednisone, my dog is back to normal! The only adverse things about Percorten are the loss of hair - if he gets shaved behind his ears for instance, the hair has trouble growing back. Percorten is also very hard on their kidney(s) so I use Milk Thistle to try to counter act it. In the end though, I'm fairly certain the steroids will cause some organ failure but without it, he would never have made it. Percorten is also very expensive, as my dog is upwards of 130lbs he requires a whole vial every month to the tune of almost $200 a pop with shipping and injection fee. But at the end of the day, he's my best friend and I would do anything for him! Love Vet Depot they are quick with shipping, always call back in a timely fashion, great customer service, etc..