Use Canine Spectra 9, Box of 25 as an annual booster to protect your dogs against Distemper, Adenovirus, Parainfluenza, and Parvo. It's also effective against Lepto and canine hepatitis. Please Note: We are unable to ship this product to the following states: CT, DE, IL, MN, NH, NJ, and NY. This product requires overnight expedited shipping and ships Monday through Thursday. During summer months, the purchase of 1 or 2 additional ice packs is advised.