Generic Anipryl MAOI for Dogs

Selegiline HCL is a monoamine oxidase inhibitor used to treat Cushing's disease and canine senility. It is very effective when used as prescribed and is the only FDA-approved drug for the treatment of canine cognitive dysfunction syndrome. When used to treat cognitive dysfunction, Selegiline HCL pet meds are most effective when used along with a behavior modification plan.

Selegiline HCL helps dogs with Cushing's disease by reducing symptoms such as polydipsia, polyuria, hair loss, thinning skin, overeating, itching, lethargy, depression, aggression, ataxia, and vomiting.

In cases of canine cognitive dysfunction syndrome, or CDS, Selegiline HCL restores and improves relationships with humans and with other dogs, minimizes disorientation, improves activity and sleep, and helps prevent inappropriate urination and defecation, thereby significantly improving quality of life.

Benefits of Selegiline HCL:

  • Generally well tolerated
  • Reduces wandering and forgetfulness in CDS
  • Improves quality and timing of sleep in CDS
  • Promotes quality interaction with family members in CDS
  • Prevents muscle wasting and improves muscle tone in dogs with Cushing's disease
  • Helps prevent corneal plaques and testicular atrophy in dogs with Cushing's disease

Use this medication only as directed by your veterinarian.

Do not allow any child to give this medication.

Before using this medication, tell your veterinarian about any other drugs or supplements your pet is currently taking.


  1. Give 0.20 to 0.45 mg per pound of body weight to dogs with Canine Cognitive Dysfunction.
  2. Give 0.45 mg per pound of body weight to dogs with Cushing's disease.
  3. Administer the medication in one daily dose, preferably in the morning.
  4. Increase the dose after 2 months if no improvement is noted and your veterinarian instructs you to do so.

Frequency of Use:

The duration of treatment depends on the type of condition being treated. Do not stop giving Selegiline HCL early, even if symptoms improve or disappear during treatment.

Do not give a double dose of this medication.


Store Selegiline HCL at room temperature, in a childproof container, away from light. Keep away from children and pets.

It is a violation of Federal Law to use this product in a manner inconsistent with its labeling.

Selegiline HCL, a monoamine oxidase inhibitor, works by increasing levels of dopamine in the brain. Dopamine is a neurotransmitter that improves many cognitive processes. Selegiline HCL is primarily used to treat canine senility, also called canine cognitive dysfunction syndrome. It may also be used to treat Cushing's disease.


Keep this product out of reach of children and animals. Do not use or store in or near open flame or heat.

Selegiline HCL is intended for use in dogs only. Not for other animals. Not for humans.

CAUTION: Selegiline HCL is an MAOI and should therefore not be used in conjunction with other antidepressants, especially fluoxetine and meperidine. This medication has many contraindications and interactions and should only be used under supervision by a veterinarian.

Side effects associated with Selegiline HCL include diarrhea, vomiting, lethargy, and restlessness. Some pets may also experience dry mouth, drowsiness, dizziness, nausea, insomnia, anxiety, or agitation while taking this medication.

Do not give this medication to pregnant or nursing animals.

Do not use this medication in animals with a known allergy to it or to similar medications.

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