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Treat your dog's Cushing's Disease with Lysodren Lysodren 500 mg, 15 Tablets (Mitotane) is used to treat pituitary-dependent hyperadrenocorticism (Cushing's Disease) and adrenal tumors in dogs. Some vets may also prescribe it to treat the symptoms of certain types of adrenal gland cancers. Lysodren works on your pet's adrenal glands so they produce less cortisol. In most Cushing's cases, treatment with Lysodren is continued for the life of the dog. Lysodren 500 mg, 15 Tablets Customer Reviews ...