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Denamarin for Dogs 13 to 34 lbs, Green, 30 Tablets
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Nutramax Laboratories Item #: 1016274 -

Denamarin for Dogs and Cats up to 12 lbs, Blue, 30 Tablets
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Nutramax Laboratories Item #: 1016273 -

Denamarin for Dogs over 35 lbs, Purple, 30 Tablets
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Nutramax Laboratories Item #: 1016322 -

Denamarin for Dogs, 30 Chewable Tablets
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Nutramax Laboratories Item #: 1030006 -

Denamarin for Dogs, 75 Chewable Tablets
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Nutramax Laboratories Item #: 1030007 -

SAMe Liver Supplements for Dogs & Cats

Rating: based on 154 reviews

What is Denamarin?

Denamarin is a nutritional supplement from Nutramax Labs that's designed to help support liver health in dogs and cats. This product contains two active ingredients--SAMe (S-Adenosylmethionine) and silybin--that work together to aid liver function.

The SAMe helps increase levels of glutathione in the liver, which is an antioxidant that's important for liver health. It also has been shown to help protect your pet's liver cells from cell death, and Denamarin may help support cell repair and regeneration. Silybin is a milk thistle extract that helps maintain a healthy oxidative balance and support liver function.

While it can sometimes be difficult to determine the exact cause behind compromised liver function, supporting your dog or cat's liver is important. Supplements like Denamarin may also be helpful for pets that take NSAIDs like Rimadyl or Deramaxx for long-term pain management.


  • Protects liver cells from death and helps repair and regenerate cells
  • Available in standard tablets for cats and dogs and chewable tablets for dogs only
  • Works by increasing antioxidant levels
  • Causes no known side effects
  • Silybin improves digestion and the absorption of nutrients from food
  • Chewable tablets available in appealing liver flavor

How Does Denamarin Work?

Denamarin supports your pet's liver function with two active ingredients: SAMe (S-Adenosylmethionine) and silybin. These two ingredients support glutathione production and help protect against cell death.

Brand Name



Nutramax Laboratories, Inc.

Active Ingredients

Denamarin for Cats & Small Dogs: 90 mg of S-Adenosylmethionine and 9 mg of silybin A+B

Denamarin for Medium Dogs: 225 mg of S-Adenosylmethionine and 24 mg of silybin A+B

Denamarin for Large Dogs: 425 mg of S-Adenosylmethionine and 35 mg of silybin A+B

Denamarin Chewable Tablets for Dogs: 225 mg of S-Adenosylmethionine and 24 mg of silybin A+B


Denamarin is an over-the-counter (OTC) supplement. It is available as boxes of 30 stabilized tablets for: cats & small dogs up to 12 lbs., medium dogs 13-34 lbs., and large dogs 35 lbs. and over. It is also available in chewable tablet form for dogs of all sizes. The chewable tablets come in bottles of 30 or 75.

Common Misspellings

Danamarin, Danemarin, Deanmarin, Deanna rin, Deemamarin, Demamarin, Demarin, Demnarin, Denamarim, Denamarom, Denamerin, Denamurin, Denararin, Denarin, Denarmarin, Denemarin, Denemerin, Denimarin, Denimerin, Denmarin, Denomarin, Denomaron, Menamarin

Warranty and Manufacturer Information

NUTRAMAX LABORATORIES, INC,. 946 Quality Drive, Lancaster, SC 29720



Denamarin Tablets NAC No.: 1291015.2

Denamarin Chewable Tablets NAC No.: 1291034.1

The above is provided for information purposes only and should not be used for the diagnosis or treatment of any condition. This information does not cover all possible variables, conditions, reactions, or risks relating to any topic, medication, or product and should not be considered complete. Certain products or medications may have risks and you should always consult your local veterinarian concerning the treatment of your pet. Any trademarks are the property of their respective owners.

How to Use Denamarin


Denamarin Tablets should be given on an empty stomach for optimal absorption, at least one hour before feeding your pet. Always make sure your pet has access to fresh water. If your pet is difficult to "pill" you can try disguising the tablet in a small bite of food or use products like Greenies Pill Pockets or Pill Wrap Paste.

The chart below is provided as a guide for administration and is based on the nearest whole-tablet. Always follow read the manufacturer's instructions and follow your veterinarian's specific guidelines for your pets.

Marin can be used in conjunction with Denamarin for additional silybin levels. If the two products are being used together, they should be administered 12 hours apart.

Denamrin for Cats & Small Dogs (Blue)

Weight Number of Tablets Per Day
Up to 12 lbs. 1 tablet
Over 12 lbs. 1 twice daily

Denamarin for Medium Dogs (Green)

Weight Number of Tablets Per Day
13-34 lbs. 1 tablet

Denamarin for Large Dogs (Purple)

Weight Number of Tablets Per Day
35-65 lbs. 1 tablet
66-120 lbs. 2 tablets
Over 120 lbs. 3 tablets

Denamarin Chewable Tablets for Dogs

Weight Number of Tablets Per Day
Up to 6 lbs. 1/4 tablet
7-15 lbs. 1/2 tablet
16-30 lbs. 1 tablet
31-45 lbs. 1 1/2 tablets
46-60 lbs. 2 tablets
61-75 lbs. 2 1/2 tablets
76-90 lbs. 3 tablets
91-105 lbs. 3 1/2 tablets
Over 105 lbs. 4 tablets

Side Effects

The manufacturer indicates there are no known side effects.


Always talk to your veterinarian before starting your pet on any new medication or supplement. Do not administer the higher dose Denamarins to animals not indicated on the packaging. Make your your pet has a source of fresh water.


Store in a cool dry place. Denamarin tablets are sensitive to moisture and extreme heat. Keep out of reach of children and animals.

Frequently Asked Questions about Denamarin

What is Denamarin and how does it work?

Denamarin is a liver health supplement for dogs and cats. It contains two active ingredients: S-Adenosylmethionine (SAMe) and silybin. They work together to support liver function, increase glutathione production, and help protect liver cells from cell death.

Which pets would benefit from Denamarin?

Pets who have compromised liver function or pets who are on NSAIDs for long-term joint pain management may benefit from supplementation with Denamarin. Talk to your veterinarian to see if they recommend starting your pet on a liver supplement.

Do I need a prescription for this?

No. Denamarin is an over-the-counter (OTC) nutritional supplement.

What are the side effects?

The manufacturer reports no known side effects.

What should I do if a side effect occurs?

Cease administering Denamarin and seek veterinary care.

Can Denamarin cause vomiting?

Although Nutramax reports no known side effects, it would be best to take your pet to their veterinarian if they vomit after taking Denamarin.

What are the differences between Denamarin, Denosyl, and Marin?

Marin and Denosyl are also manufactured by Nutramax. The former contains only silybin, while the latter contains only SAMe (S-Adenosylmethionine). Denamarin has both those ingredients in one supplement.

What size should I buy?

Denamarin tablets are available in three sizes: for cats and small dogs up to 12 lbs., for medium dogs 13-34 lbs., and for large dogs weighing more than 35 lbs. The chewable tablets can be given to dogs of all sizes.

Do not give a dosage indicated for dogs only to cats.

Is there a liquid form?

No. Denamarin is only available as standardized tablets or chewable tablets.

My dog won't swallow the pills. What should I do?

You can try wrapping the tablets with food. Alternatively, VetDepot carries a variety of pill pockets to use with pets that don't like taking medications.

How long should you wait to feed your dog after giving Denamarin?

Nutramax recommends giving Denamarin at least 1 hour before feeding your pet.

Can I split the pills in half?

The regular stabilized tablets are specially coated so that they remain intact as they pass through the stomach. Splitting them in half or crushing them up will make them vulnerable to your pet's stomach acid. The chewable tablets can be split in half however.

Can I give this to myself?

Denamarin is for veterinary use only.

How is Denamarin different from the SAMe I can buy in stores?

The SAMe you can buy at the store is formulated for human consumption. The doses in those products are too high for animal use. Denamarin is specifically formulated for veterinary use.

Where is this manufactured?

Nutramax has two facilities in the US: Maryland and South Carolina.

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