Marquis for Horses

Equine Protozoal Myeloencephalitis (EPM) Treatment

Marquis Antiprotozoal Oral Paste is an anticoccidial medication indicated for the treatment of EPM, or equine protozoal myeloencephalitis. EPM is a progressive and degenerative disease that attacks the central nervous system in horses, resulting in severe disability and death. Marquis is able to treat the parasites responsible for EPM more quickly and affordably than other medications.

Benefits of Marquis:

• First approved medication for the treatment of EPM
• Easy to dose and administer
• Generally well tolerated
• Effective against the Sarcocystis parasites at several lifecycle stages
• Crosses the blood/brain barrier to reach and kill the parasite
• Works quickly to reduce treatment duration and potential for side effects
• Readily accepted by most horses

Use this medication only as directed by your veterinarian.

The recommended dosage of Marquis is 2.27 mg per pound of body weight once each day for 28 days.

Assemble the paste syringe prior to administration.

Assembly Directions:

1. Check that the plunger is clean and completely dry. Verify that the end cap is on the syringe barrel.
2. Insert the plunger into the base of the syringe barrel. You will feel it snap into place.
3. Remove the end cap and apply pressure to the plunger until you see paste at the tip of the barrel.
4. Place the end cap back on the tip of the syringe.

Usage Directions:

1. Remove the end cap from the syringe and apply pressure to the plunger until you see paste at the barrel's tip.
2. Place the end cap back on the tip of the syringe.
3. Check your horse's mouth to make certain it is clear of feed.
4. Measure the correct dose based on your horse's weight by rotating the dosage ring on the plunger to the appropriate weight mark. The ring collar and barrel collar should be flush.
5. Remove the end cap from the tip of the barrel.
6. Introduce the tip of the syringe into the side of your horse's mouth, between the front and back teeth.
7. Depress the plunger to deposit the correct amount of paste onto the top and back of your horse's tongue.
8. Remove the syringe from your horse's mouth.
9. Immediately raise your horse's head for several seconds. This will encourage swallowing of the paste.
10. Wipe the tip of the syringe with a towel to clean it, and then return the end cap to the tip.
11. Repeat these instructions each day for the prescribed treatment period.

Frequency of Use:

The usual duration of treatment is 28 days. Your veterinarian may prescribe treatment for a shorter or longer period, depending on the severity of your horse's illness and other factors.

Storage:

Store Marquis at controlled room temperature, 59 to 86 degrees F. Store in a light-resistant, tightly closed container. Keep out of reach of children and pets.

It is a violation of Federal Law to use this product in a manner inconsistent with its labeling.

Active Ingredients: 15% w/w ponazuril

Warnings:

Keep this product out of reach of children and animals. Do not use or store in or near open flame or heat.

Marquis is intended for use in horses only. Do not use in horses intended for consumption. Not for use in other animals. Not for humans.

CAUTION: Before beginning therapy with Marquis, other diseases able to produce ataxia in horses should be ruled out.

It is not established if Marquis is safe for use in breeding, pregnant, or lactating mares. Use cautiously.

Side effects are uncommon and may include mouth and nose blisters, skin rash, hives, colic, seizures, or other symptoms.

Some horses may have developed irreversible damage from EPM prior to treatment with Marquis. Marquis cannot reverse this damage.

Do not use this medication in animals with a known allergy to it or to similar medications.

Warranty and Manufacturer Information:

BAYER HEALTHCARE LLC

Animal Health Division

P.O. BOX 390, SHAWNEE MISSION, KS, 66201-0390

Customer Service Tel.: 800-633-3796

Customer Service Fax: 800-344-4219

Website: www.bayer-ah.com

U.S. Patent No. 5,883,095

08715532-79004570, R.3

©2004 Bayer HealthCare LLC

April, 2004

Manufactured by Bayer HealthCare LLC, Animal Health Division, Shawnee Mission, Kansas 66201 U.S.A.

NADA # 141-188, Approved by FDA

www.epminfo.com