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Comfortis for Dogs

Products 1-6 of 6
Comfortis for Cats 2-4 lbs & Dogs 3.3-4.9 lbs, 6 Pack (Yellow)
Availability: Rx Required
Retail: $107.99
Price: $77.77
Item #: 1018415 -
Comfortis for Dogs 10-20 lbs, Orange, 6 Pack
Availability: Rx Required
Retail: $120.99
Price: $87.27
Item #: 1016577 -
Comfortis for Dogs 20-40 lbs, Green, 6 Pack
Availability: Rx Required
Retail: $125.99
Price: $91.27
Item #: 1016578 -
Comfortis for Dogs 40-60 lbs, Blue 6 Pack
Availability: Rx Required
Retail: $128.99
Price: $92.77
Item #: 1016579 -
Comfortis for Dogs, 5-10 lbs, Pink, 6 Pack
Availability: Rx Required
Retail: $119.99
Price: $86.27
Item #: 1016576 -
Comfortis for Dogs 60-120 lbs, Brown, 6 Pack
Availability: Rx Required
Retail: $132.99
Price: $96.27
Item #: 1016580 -
Products 1-6 of 6

Dogs Flea Treatment & Control Medication

Comfortis is a prescription flea control medication for dogs that kills fleas for up to one month. Beef-flavored chewable tablets make it easy to administer Comfortis flea treatment to your dog. Comfortis is available in 6 month packs for extra-small dogs 5-10 lbs., small dogs 10-20 lbs., medium dogs 20-40 lbs., large dogs 40-60 lbs., and extra-large dogs 60-120 lbs.

Comfortis is the first FDA-approved, beef-flavored chewable tablet available to eliminate and prevent flea infestations on dogs for one month. The product works rapidly to kill existing fleas and break the flea life cycle.

Benefits of Comfortis:

  • Begins working to kill fleas within 30 minutes
  • 100 percent effective within 4 hours of administration
  • Protects dogs for a full month
  • Improves symptoms of flea allergy dermatitis by eliminating flea bites
  • Destroys fleas before they are able to lay eggs to effectively end the flea life cycle
  • Available in a convenient beef-flavored, chewable tablet
  • The active ingredient in Comfortis, spinosad, is not harmful to the environment

For Use In: Dogs and puppies 14 weeks of age or older. Comfortis is not for use in cats or other animals.

Keep out of reach of children. Do not allow children to handle Comfortis. Read directions and precautionary statements before use.


Give Comfortis to your dog once per month by mouth.The recommended dose of Comfortis is 13.5 mg/lb. Offer Comfortis with food or just before meals to encourage acceptance.

Body Weight

Spinosad Per Tablet (mg)

Tablets Administered

5 to 10 lbs



10.1 to 20 lbs



20.1 to 40 lbs



40.1 to 60 lbs



60.1 to 120* lbs



* Dogs over 120 lbs should be administered the appropriate combination of tablets.

Frequency of Use:

Administer Comfortis chewable tablets once monthly.

Begin treatment during any season. Effectiveness is improved when Comfortis is started one month before active flea season. Continue the product without interruption in areas where fleas are common year-round.


Store in original container and out of reach of children and animals.

Store this product at room temperature.

It is a violation of Federal Law to use this product in a manner inconsistent with its labeling.

Spinosad, the active ingredient in Comfortis, excites the nervous system of fleas by activating nicotinic acetylcholine receptors. This action leads to paralysis and death. Comfortis chewable tablets are available in five sizes: 140 mg, 270 mg, 560 mg, 810 mg, and 1620 mg.

Comfortis is only available by prescription.

Active ingredients: Spinosad


Keep this product out of reach of children and animals. This medication is not for use in humans. There are no known contraindications for using Comfortis.

Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

CAUTION: Comfortis may cause depression, vomiting, lethargy, ataxia, diarrhea, anorexia, trembling, itching, hypersalivation, and/or seizures.

Using ivermectin with Comfortis may cause serious adverse reactions, including seizures, twitching, trembling, ataxia, blindness, drooling, and disorientation.

Report an adverse drug reaction by calling 1-888-545-5973. Additional information can be found at www.comfortis4dogs.com.

Caution is required when using Comfortis in epileptic or breeding dogs.

Warranty and Manufacturer Information:

NADA 141-277, Approved by FDA

Manufactured for Elanco Animal Health, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285

PA9184DEAMP (V02-06-2009)

NDC 0986-4222-06

NDC 0986-4223-06

NDC 0986-4224-06

NDC 0986-4225-06

NDC 0986-4227-06






NAC No.: 10310430