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Sulfasalazine is an antibiotic and anti-inflammatory drug. The oral tablets are primarily used to treat inflammatory conditions in the gastrointestinal tract, such as inflammatory bowel disease (IBD) and colitis. Sulfasalazine is sometimes used to remedy other inflammatory disorders, such as vasculitis. The medication is not FDA-approved for use in animals, but veterinary prescriptions are a common practice.

Sulfasalazine kills bacteria to treat infections and reduces inflammation. In cats and dogs, it is most often used to treat inflammatory bowel disease and colitis. It also treats vasculitis and other conditions. Sulfasalazine is better tolerated than many other anti-inflammatory medications.

Benefits of Sulfasalazine:

  • Works as an antibiotic
  • Reduces inflammation, especially in the digestive tract
  • Treats inflammatory bowel disease (IBD), chronic colitis, vasculitis, and other disorders
  • Causes fewer and milder side effects than many other ant-inflammatory drugs
  • Prescription-strength treatment
  • Low-cost generic product

Read all instructions and precautionary statements provided by the manufacturer before using this product.

Symptoms may disappear before an infection is fully treated. Do not stop administration before completion of the prescription.

The following directions represent a standard use. Follow the specifications of your veterinarian's prescription.


  1. Give with or shortly after food.
  2. Administer 10 to 15 mg per pound of body weight every 8 hours to dogs.
  3. Administer 5 to 10 mg per pound of body weight once daily to cats.
  4. Provide plenty of fresh water to pets during treatment.

Frequency of Use:

Dogs are typically dosed 4 times per day, while cats are typically dosed once per day.

Give a forgotten dose as soon as you remember it. However, if it is almost time for the next dose, wait and resume the prescribed schedule then. Do not give a double dose.


Keep out of reach of children and animals.

Store Sulfasalazine at room temperature. Protect from moisture and heat.

It is a violation of Federal Law to use this product in a manner inconsistent with its labeling.

Sulfasalazine is an antibiotic and an anti-inflammatory agent. Its exact mechanisms of action are unknown. However, it is believed that Sulfasalazine inhibits the actions of certain bodily substances that trigger inflammation, tissue damage, and diarrhea. Most of the drug is not absorbed into the bloodstream; rather, it remains in the intestines, where it works topically to reduce inflammation.

Sulfasalazine Active Ingredient (per tablet): sulfasalazine 500 mg


Keep Sulfasalazine out of reach of children and animals. Do not use or store in or near open flame or heat.

Sulfasalazine is intended for use in cats and dogs. Do not administer to other species. Use only in the animal for which it was prescribed.

Use as prescribed by your veterinarian.

CAUTION: Clinical signs of an infection may clear up before the infection. Do not stop giving your pet Sulfasalazine until the prescribed regimen is completed.

Do not give at higher doses or for a longer duration than prescribed.

Sulfasalazine can interact with other drugs and supplements. Talk to your veterinarian before concomitantly using any other medications or supplements in your pet during treatment.

Not for use in any animal with a hypersensitivity to it or other sulfa drugs.

Tell your veterinarian if your pet has had an intestinal or urinary tract blockage, renal or hepatic impairment, porphyria, or glucose-6 phosphate dehydrogenase deficiency. Tell your veterinarian if your pet is pregnant or lactating.

Seek immediate veterinary treatment for an overdose. Symptoms may include nausea, emesis, stomach pain, drowsiness, or seizures.

If colitis or another condition fails to improve or worsens with administration, or if your pet experiences sore throat, fever, or yellowing of the eyes, discontinue use and consult your veterinarian right away.

Other side effects may include nausea, emesis, diminished appetite, fever, headache, itching, rash, hives, dry eye, and others. Consult your veterinarian about any that are particularly bothersome to your pet.

Pets require plenty of fresh water during treatment.

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