A few years ago our Vet suggested these supplements for our Golden Retriever who had had trouble with Hot Spots at least once a year. Since he has been on these he has had no trouble until this year and I feel it was because when we went on a short vacation he did not have these given to him. We did not board him-just had a friend come by and feed/water him. Not to impose on this favor, we did not request that he give him these supplements. Our dog ended up with a Hot Spot a little while after we came back and had to be treated by a Vet. I am convinced that the dog has benefited greatly from this product.