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Simplicef 100 mg, 10 Tablets
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Simplicef 100 mg, 100 Tablets
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Simplicef 100 mg, One Tablet
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Simplicef 200 mg, 10 Tablets
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Simplicef 200 mg, 100 Tablets
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Simplicef 200 mg, One Tablet
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Products 1-6 of 6

Cephalosporin Antibiotics for Dogs

Cefpodoxime proxetil, the active ingredient in Simplicef, is a cephalosporin antibiotic that suppresses the growth of microorganisms, including bacteria, fungi, and protozoa. It effectively kills many types of gram-positive and gram-negative bacteria. This gives Simplicef for dogs broad-spectrum action against an array of bacterial infections.

Comparable Trade Names & Generics

Simplicef is an antibiotic for dogs that kills many types of bacteria. It effectively treats a variety of skin, ear, urinary tract, respiratory tract, and bone infections. Administer Simplicef only once per day to treat your dog's infection.

Benefits of Simplicef:

  • Treats skin infections, including wounds and abscesses
  • Treats urinary tract infections (UTIs)
  • Treats respiratory infections, including pneumonia and bronchitis
  • Treats ear infections
  • Treats bone infections
  • Once-daily oral tablets given with or without food for ease of administration
  • Rarely causes side effects, and those that do occur are usually minor

Simplicef is only for use in dogs. Do not administer to cats or other animals. Not for use in humans.

Do not permit children to give Simplicef to your pet.

Review manufacturer warnings and instructions before use.

Dosage depends on various factors, among them the severity and location of the infection and the type of bacteria. Use as prescribed by your veterinarian.


  1. Remove only the current dose and then tightly reseal the bottle and return it to its safe storage location.
  2. Administer 2.3 to 4.5 mg per pound of body weight, as prescribed.
  3. Give dose once per day by mouth, with or without food.
  4. Continue treatment for 5 to 7 days or for 2 to 3 days after symptoms are gone, as prescribed.

Frequency of Use:

Simplicef is given once daily. Not to be used for more than 28 days.

Give a missed dose as soon as you remember it. If it is almost time for the next dose, just wait; never give a double dose of Simplicef unless your veterinarian instructs it.


Keep out of reach of children and animals.

Store Simplicef in its original container, tightly sealed. Keep bottle in a cool, dry place not to exceed 77 degrees F.

It is a violation of Federal Law to use this product in a manner inconsistent with its labeling.

Simplicef (Cefpodoxime proxetil)

Simplicef Tablets Active Ingredient: cefpodoxime (100 mg or 200 mg available)


Keep this product out of reach of children and animals. Do not use or store in or near open flame or heat.

Simplicef is only intended for use in dogs. Not for use in other animals or humans.

Do not give Simplicef at the same time as an antacid or other stomach acid-reducing medication.

If there is no response to treatment of an acute infection within 3 to 4 days, consult your veterinarian about the need for an alternative therapy.

Simplicef, like other cephalosporins, may occasionally induce a positive direct Coombs' test.

CAUTION: Tell your veterinarian if your dog is or may become pregnant, if your dog is lactating, or if your dog is used for breeding. Tell your veterinarian if your pet has a history of seizures, epilepsy, renal disease, or any stomach or intestinal disease.

Side effects are rare, but may include nausea, diarrhea, and yeast infection. If any adverse reactions seem worrisome or bothersome to your dog, mention them to your veterinarian.

Make certain your veterinarian knows if your dog has a hypersensitivity to any penicillin or cephalosporin.

Diarrhea, vomiting, mucous or blood in the stool, itching, rash, hives, difficulty breathing, facial swelling, abnormal bleeding, bruising, and fainting may indicate an allergic reaction. Seek emergency veterinary treatment.

Nausea, vomiting, diarrhea, and abdominal cramps may indicate an overdose. Contact your veterinarian right away if an overdose may have occurred.

Tell your veterinarian if your dog is taking any other antibiotics, a loop diuretic, or probenecid for possible dosage adjustments. Other drugs and supplements may interact with Simplicef, so consult your veterinarian before using any others concurrently with this product.

Warranty and Manufacturer Information:

NADA # 141-232, Approved by FDA

Distributed by: Pharmacia & Upjohn Company, Division of Pfizer Inc, New York, NY 10017

Made in Belgium

Revised July 2004

819 826 001



NAC No.: 10490620