Sentinel

Dogs Heartworm Preventative & Flea control Medicine

Sentinel is the only effectively monthly preventive treatment that protects against heartworms and adult hookworms, roundworms, and whipworms. Sentinel also stops flea egg development to prevent and treat flea infestations.

A single female flea produces as many as 2,000 eggs during her lifetime. Sentinel prevents these fleas from developing to control flea infestations on dogs.

Benefits of Sentinel:

• Effective heartworm prevention and flea control for dogs
• Breaks the flea life cycle by halting egg development
• Reduces risk of tapeworm infections
• Helps prevent flea allergy dermatitis by stopping flea bites
• Tasty, flavored chewable tablets
• Convenient and easy to administer
• When used concurrently with Capstar tablets, Sentinel provides a very effective system for managing fleas in dogs

Sentinel is approved for use in dogs only. Do not give Sentinel to cats or to any other animals.

Keep out of reach of children. Do not allow children to administer Sentinel. Read directions and precautionary statements before use.

Directions:

1. Test your dog for heartworms prior to beginning heartworm prevention medication.
2. Weigh your dog prior to administering Sentinel to ensure proper dosing.
3. Remove Sentinel from its packaging just before giving the product to your dog.
4. Administer one tablet containing 2.3 mg of Milbemycin Oxime and 46 mg of lufenuron to dogs weighing 2 to 10 lbs.
5. Administer one tablet containing 5.75 mg of Milbemycin Oxime and 115 mg of lufenuron to dogs weighing 11 to 25 lbs.
6. Administer one tablet containing 11.5 mg of Milbemycin Oxime and 230 mg of lufenuron to dogs weighing 26 to 50 lbs.
7. Administer one tablet containing 23 mg of Milbemycin Oxime and 460 mg of lufenuron to dogs weighing 51 to 100 lbs.
8. Speak with your veterinarian about dosing for dogs weighing more than 100 lbs.
9. Monitor your dog to make certain the entire dose of Sentinel is swallowed. If your dog spits out the entire product, promptly administer one more full dose. If a partial dose is swallowed, consult your veterinarian for advice.

Frequency of Use:

Administer Sentinel once a month on the same day of each month. Continue this schedule year-round, unless otherwise instructed by your veterinarian.

Storage:

Store this product at room temperature, away from pets and children. Keep this product inside its original packaging until ready to use.

It is a violation of Federal Law to use this product in a manner inconsistent with its labeling.

Milbemycin oxime, one of Sentinel's active ingredients, may work by interfering with invertebrate neurotransmission. Lufenuron, the other active ingredient in Sentinel Flavor Tabs, inhibits the development of flea eggs to break the flea life cycle and control infestations. Lufenuron does not affect adult fleas.

Sentinel (milbemycin oxime/lufenuron)

Active ingredients: Milbemycin Oxime, Lufenuron

Warnings:

Keep this product out of reach of children and animals.

It is not know if the concurrent use of Sentinel and Capstar is safe for pregnant or nursing dogs. It is not know if the concurrent use of Sentinel and Capstar is safe for puppies less than 11 weeks of age.

Sentinel is intended for use in dogs and puppies older than 4 weeks of age and weighing more than 2 lbs.

Sentinel may cause adverse effects in some dogs, including vomiting, urticaria, lethargy, depression, itching, anorexia, diarrhea, ataxia, skin congestion, hypersalivation, weakness, and convulsions.

CAUTION: It is important to test and treat for adult heartworms before beginning preventative care with Sentinel. Dogs carrying a large number of heartworm microfilariae have shown hypersensitivity reactions to Sentinel that included labored breathing, vomiting, lethargy, and salivation.

Seek immediate veterinary attention for possible overdose. Symptoms of overdose may include depression, vomiting, drowsiness, diarrhea, loss of appetite, seizures, hypersalivation, and weakness.

Use caution when giving Sentinel to dogs also taking amiodarone, azole antifungals, carvedilol, cyclosporine, erthromycin, diltiazem, quinidine, clarithromycin, spironolactone, verapamil, or tamoxifen.

Warranty and Manufacturer Information:

Manufactured for: Novartis Animal Health US, Inc., Greensboro, NC 27408

NADA #141-204, Approved by FDA

© 2007 Novartis Animal Health US. Inc.

SENTINEL, Flavor Tabs and CAPSTAR are registered trademarks of Novartis AG.

NAH/SEN-FT/VIPI-FMS/2

2003340

12/07

NAC No.: 11310097