Sedivet 1% Injection is a sedative with analgesic properties. This product may also be used as a preanesthetic agent. It is administered intravenously. Sedivet requires a veterinary prescription.

Sedivet sedates and provides analgesic effects for adult horses. It facilitates handling and restraint for veterinary examinations and procedures and minor surgeries. It also serves as a preanesthetic to allow for reduced use of anesthesia to minimize associated risks.

Benefits of Sedivet 1% Injection:

  • Sedates horses
  • Facilitates handling and restraint
  • Useful prior to clinical examinations and procedures and minor surgery
  • Dulls pain
  • Works as a preanesthetic administration
  • Reduces the need for, and risks associated with, anesthesia
  • Fast-acting

Read all label instructions and precautionary statements before use.

Note that analgesia does not last as long as sedation with Sedivet.

For use by or under the close supervision of a veterinarian.


  1. Allow horse to rest calmly for several minutes before and after use.
  2. For sedation and analgesia, administer Sedivet slowly via intravenous injection. Dose at 0.4 to 1.2 mL per 220 lbs. of body weight depending on depth and duration of sedation required. At all doses, onset of sedation should occur within 2 to 4 minutes and onset of analgesia should occur in 5 minutes. At the lowest dose, sedation should last for 75 minutes and analgesia should last for 30 minutes; at the highest dose, sedation should last for 3 hours and analgesia should last for 150 minutes.
  3. For preanesthesia, administer a single intravenous injection. Dose at 1.0 mL per 220 lbs. of body weight. Induce anesthesia after maximum sedation occurs, at appropriately reduced levels. Onset of mild to moderate sedation is within 2 to 4 minutes. Lateral recumbency occurs within 4 minutes of induction and complete anesthesia occurs within 6 to 16 minutes. During recovery, sternal recumbency occurs in 12 to 83 minutes and standing occurs in 17 to 84 minutes. Recovery time varies according to choice of anesthetic and duration of anesthesia.

Frequency of Use:

Sedivet is given in a single administration.


Keep out of reach of children and animals.

Store Sedivet at room temperature between 59 and 86 degrees F.

It is a violation of Federal Law to use this product in a manner inconsistent with its labeling.


Keep Sedivet out of reach of children and animals. Do not use or store in or near open flame or heat.

Sedivet is only intended for use in adult horses. Do not administer to other animals. Not for use in humans.

CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Not for use in horses intended for human consumption.

Do not give Sedivet to any horse with a hypersensitivity to romifidine.

Epinephrine should be avoided, as it can potentiate the effects of a product containing an a2-adrenoceptor agonist.

Rarely, anaphylactic reactions have occurred, including at least one of the following: edema of the upper airways and head, trembling, urticaria, dyspnea, recumbency, and subsequent death.

Do not use intravenous potentiated sulfonamides in sedated or anesthetized horses; potentially fatal cardiac dysrhythmias may result.

Even when appearing deeply sedated, external stimuli may still prompt kicking or other defensive actions in horses. Use appropriate safety precautions at all times.

Avoid contact with skin, eyes, and mouth. Romifidine is an irritant and can be absorbed through the skin. Remove contaminated clothing and wash affected skin with soap and water. Flush eyes for 15 minutes in the event of contact. Seek medical attention for accidental ingestion. If any contact results in continuing irritation, seek medical attention.

Sedivet contains an a2-adrenoceptor agonist that may be absorbed via dermal and oral routes.

Take precautions to prevent inadvertent self-injection when handling Sedivet. People being treated for blood pressure problems should be particularly careful when handling Sedivet.

This product can compound the effects of other products containing an a2-adrenoceptor agonist, so should not be used concomitantly with any such product.

Concurrent use of other sedatives, tranquilizers, or oropioids can increase the effects of Sedivet. 

The use of anesthesia following administration of Sedivet should be reduced to prevent excessive depression of the central nervous system.

The safety of Sedivet in pregnant mares, foals, and horses used for breeding has not been determined.

The safety of Sedivet in horses with impaired cardiovascular function has not been determined. This product's adverse effects on animals with primary myocardial disease or circulatory shock may be significant.

The safety of Sedivet in horses with colic has not been determined.

Not for use in horses with kidney or liver disease, respiratory disease, dehydration, or other systemic conditions that compromise health.

As with similar drugs, Sedivet may cause a drop in blood pressure, bradycardia (sometimes severe), first and second-degree atrioventricular heart block. The frequency and duration of cardiac arrhythmias have been demonstrated to be related to the dose administered.

Side effects of drugs containing an a2-adrenoceptor agonist may include increased or decreased blood pressure, salivation, perspiration, muscle tremors, flatulence, ataxia, bradycardia, piloerection, urination about 1 hour post-administration, relaxation of the penis, head lowering (causing congestion and facial or upper airway swelling), mild colic, stridor, and diminished gastrointestinal motility.

As with other drugs of the same class, administration of Sedivet may rarely have a paradoxical result, causing excitation.

Warranty and Manufacturer Information:


2621 North Belt Highway, St. Jospeh, MO, 64506-2002


NADA 141-229, Approved by FDA

NAC No.: 10281500

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