My vet had recommended Dasuquin for my 10 year old royal standard poodle Bailey, expensive with no noticeable difference. However, while road tripping in the pacific northwest this past summer, a vet in Lake Oswego suggested the S3 Soft Chews. The difference was amazing and immediate!!! Upon returning home, we could not find this product at any vet office in the area. We were delighted to find Vet Depot online...who not only carried the chews, but the price was better, great customer service, and free shipping!