My Halequin Great Dane was having some sort of an allergic reaction that caused large, red, sore looking, itchy patches on her skin. Oral steroids would only clear it up as long as she stayed on them and she developed all of the usual steroid side effects. Not an acceptable long term solution. I took her to a second Vet who recommended washing her with PhytoVet CK Antiseptic Shampoo fallowed by ResiCORT Leave-On Lotion two to three times a week. It took about six weeks to completely clear skin. Now she's her usual happy, fit, beautiful, goofy self. I would highly recommend this product.