Estrus Suppression Pet Medications for Horses

Regu-Mate is a pet medication that provides an oral form of progestin which suppresses estrus in mares. Regu-Mate for horses helps the mare attain regular cyclicity during the transition to breeding season.

Regu-Mate is a synthetic version of the hormone progesterone that works to prevent estrus in mares or control the start of estrus. By suppressing estrus, Regu-Mate helps mares attain regular cycles, allows for scheduled breeding, and shortens prolonged estrus.

Benefits of Regu-Mate:

  • Easy to administer top-dressed or by mouth
  • Suppresses estrus in 95% of mares within 3 days of beginning therapy
  • 15-day treatment may improve performance by making mares more predictable
  • Helps regulate prolonged estrus
  • Can prevent moodiness and other issues associated with hormonal fluctuations
  • Powerful prescription medication

Use Regu-Mate only as directed by your veterinarian.

Always wear protective gloves when administering or working with Regu-Mate.

Women of childbearing age must use extreme caution when handling or administering this medication.


  1. Remove cap and seal and replace with plastic dispensing cup.
  2. Remove cover from dispensing tip and connect the luer lock syringe.
  3. Draw out the appropriate amount of Regu-Mate and then detach the syringe. Do not remove the syringe while the bottle is still inverted; doing so may result in spillage of the product.
  4. Give 1 mL per 110 lbs. of body weight once each day for 15 days.
  5. Give by mouth or top-dress your mare's feed.
  6. Replace cover on the dispensing tip before storing.

Frequency of Use:

Give for 15 consecutive days, once per day.


Store Regu-Mate in a tightly fitting, light-resistant container at controlled room temperature. Use 150 mL bottle within 14 days of opening; use the 250, 300, and 1000 mL bottles within 28 days of opening. Keep away from pets and children.

It is a violation of Federal Law to use this product in a manner inconsistent with its labeling.

Regu-Mate works by increasing levels of progesterone. When levels increase, the body halts estrus. Regu-Mate typically works within 3 days of beginning treatment and most mares return to estrus within 5 days of treatment.

Active Ingredient (per mL): altrenogest 2.2 mg


Keep this product out of reach of children and animals. Do not use or store in or near open flame or heat.

Regu-Mate is intended for use in mares only. Not for use in male horses. Not for use in any other animal or by humans.

CAUTION: Do not use Regu-Mate in horses with endometriosis or other inflammation of the uterus. Do not give to horses that are or could be pregnant.

Tell your veterinarian about any other medications or supplements your mare is taking before beginning therapy with Regu-Mate.

Humans who are pregnant or might be pregnant or who have liver disease, clotting disorders, breast cancer or other cancers, or a history of stroke should not handle or administer Regu-Mate. Also, do not come into contact with this medication if you have undiagnosed vaginal bleeding, cerebrovascular disease, coronary artery disease, or tumors that developing during treatment with oral contraceptives.

Avoid skin contact with this medication. Use rubber gloves when handling and wash hands with soap and water after touching this product or its container.

Do not use Regu-Mate in mares with a treated or existing uterine infection.

Do not give to male horses.

Side effects of use include changes in blood potassium and calcium levels and altered liver enzymes.

Regu-Mate may interact with rifampin.

Do not use Regu-Mate in animals with a known allergy to it or to similar products.

Warranty and Manufacturer Information:

Intervet Schering-Plough

* US Patents 3,453,267; 3,478,067; 3,484,462

Manufactured by: DPT Laboratories, San Antonio, TX 78215

Distributed by: Intervet Inc., Millsboro, DE 19966

NADA # 131-310, Approved by FDA


648730 A

NAC No.: 11061632

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