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GenOne Topical Spray, 120 mL
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Retail: $16.09
Retail: $16.09
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Availability: Prescription Required
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Availability: Prescription Required
VetOne Item #: 1017449 -

Gentamicin Spray for Skin Infections

GenOne Spray is a combination broad-spectrum antibiotic and corticosteroid. It treats skin infections caused by bacteria susceptible to gentamicin. It also remedies the itchiness, inflammation, and irritation associated with infected superficial lesions. 

GenOne provides broad-spectrum antibacterial action to treat skin infections on dogs. It also contains a corticosteroid for anti-inflammatory and anti-itch relief at the site of infection. GenOne's spray form allows for easy topical application.

Benefits of GenOne:

  • Antibiotic effective against many common types of bacteria
  • Treats infected skin lesions
  • Soothes inflammation
  • Reduces itching
  • Helps prevent scratching and further irritation or injury at the site of infection
  • Topical spray allows for easy use
  • Prescription-strength treatment of infections without oral dosing

GenOne is only for use on dogs. Do not use on cats or other animals. Not for human use.

Read all package instructions and precautionary statements before use.

Follow the instructions given in your veterinarian's prescription.


  1. Trim excessive hair around the site of infection.
  2. Clean the lesion and surrounding skin.
  3. Keep the spray bottle upright and hold its head 3 to 6 inches from the infection.
  4. Depress the sprayer head fully 2 times (each depression applies 0.7 mL of GenOne).
  5. Apply 2 to 4 times per day as prescribed for 7 days.

Frequency of Use:

Frequency varies; follow your veterinarian's prescription.


Keep out of reach of children and animals.

Store GenOne Spray bottle in an upright position between 36 and 86 degrees F.

It is a violation of Federal Law to use this product in a manner inconsistent with its labeling.

Gentamicin, one of the active ingredients in GenOne Spray, is a broad-spectrum antibiotic. It is effective against a number of gram-positive and gram-negative bacteria. Betamethasone, the product's other active ingredient, is a synthetic corticosteroid that reduces inflammation and itchiness associated with an infection when applied topically.

GenOne Ingredients (per mL): gentamicin sulfate equivalent to 0.57 mg gentamicin base, betamethasone valerate equivalent to 0.284 mg betamethasone, 163 mg isopropyl alcohol, propylene glycol, methylparaben and propylparaben as preservatives, purified water q.s. Hydrochloric acid may be added to adjust pH.


Keep this product out of reach of children and animals. Do not use or store in or near open flame or heat.

GenOne is only for dogs. Do not use on humans or other animals. Use only on the dog to which this product was prescribed.

For topical use only.

Use exactly as prescribed by your veterinarian.

CAUTION: If an allergic reaction occurs, seek emergency veterinary attention. Signs may include sudden-onset diarrhea, vomiting, facial swelling, itching, rash, hives, difficulty breathing, seizures, shock, or coma.

When given to animals during the final trimester of pregnancy, oral and parenteral administration of corticosteroids may induce the first stage of parturition and may trigger premature parturition followed by dystocia, fetal death, retained placenta, and metritis. In addition, dogs given corticosteroids during pregnancy have produced offspring with cleft palate, deformed forelegs, phocomelia, and anasarca.

Systemic and parenteral use of synthetic corticosteroids in dogs have produced SAP and SGPT enzyme elevations, loss of appetite, weight loss, diarrhea (with and without blood), vomiting, and increased thirst or urination as side effects. Canine Cushing's syndrome has been seen with prolonged or repeated steroid therapy.

GenOne is generally well tolerated when used as prescribed. If you notice any adverse reactions in your dog, consult your veterinarian.

Your veterinarian should determine whether the bacteria causing your pet's infection is susceptible to gentamicin before prescribing this product. Use of a topical antibiotic on non-susceptible bacteria can cause the infection to become worse. If your dog's infection does not appear to be improving within a few days, consult your veterinarian.

Application for more than 7 consecutive days may impair wound healing. Monitor pets closely during prolonged administration.

If your pet ingests this product, contact your veterinarian right away.

In the event of human ingestion, contact a physician or poison control center immediately with the product label on hand.

Talk to your veterinarian before using other medications or supplements while using GenOne.

Warranty and Manufacturer Information:

Manufactured for: MWI Veterinary Supply, Meridian, ID 83680

(888) 694-8381

NAC No.: 13150100

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