Fludrocortisone for Addison's Disease in Pets

Florinef is a corticosteroid medication used to treat pets with adrenal insufficiencies like Addison's Disease. Florinef pet meds should not be used as an anti-inflammatory for diseases like arthritis or certain allergies. The Fludrocortisone currently available is a low-cost, generic alternative to Florinef.

Fludrocortisone treats Addison's disease and other conditions of adrenal insufficiency in cats and dogs. It helps the kidneys properly balance the sodium and potassium levels in the blood. This product is easily given orally and generally only requires a single daily administration.

Benefits of Fludrocortisone:

  • Treats Addison's disease
  • Treats other conditions involving adrenocortical insufficiency
  • Promotes appropriate electrolyte and fluid balance
  • Highly effective
  • Easily administered oral tablets
  • Once-daily dosing in most cases
  • Lower cost generic equivalent to Florinef

Read the instructions and precautionary statements on the label before use.

The following directions represent a typical usage. Administer Fludrocortisone exactly as prescribed by your veterinarian.


  1. Give Fludrocortisone with food.
  2. Administer 0.1 mg daily to cats.
  3. Administer 0.009 mg per pound of body weight daily to dogs.
  4. Allow unrestricted access to fresh water during treatment.

Frequency of Use:

Fludrocortisone is usually given once per day.

Give a missed dose as soon as possible, unless it is almost time for the next dose. In these instances, skip the missed dose and resume the normal administration schedule at the next dose. Do not give a double dose of Fludrocortisone.


Keep out of reach of children and animals.

Store Fludrocortisone in its original container, tightly sealed, at room temperature.

It is a violation of Federal Law to use this product in a manner inconsistent with its labeling.

Fludrocortisone supplies steroids similar to aldosterone when the body does not endogenously produce adequate levels, exerting a strong mineralocorticoid effect. It improves the kidney's ability to properly balance the amounts of sodium and potassium in the blood.

Active Ingredient (per tablet): fludrocortisone acetate 0.1 mg


Keep Fludrocortisone out of reach of children and animals. Do not use or store in or near open flame or heat.

Fludrocortisone is intended for use in cats and dogs. Do not administer to other species. Use only in the animal for which it was prescribed.

CAUTION: Do not stop administration suddenly in any pet that has been taking Fludrocortisone for at least a few weeks. In many instances, this medication should be gradually reduced.

Give with food and provide plenty of fresh water for pets during therapy.

Not for use in any animal with a serious bacterial, fungal, or viral infections.

Fludrocortisone inhibits the body's ability to fight infections and can mask symptoms of illness. Avoid sources of infection during therapy.

Tell your veterinarian if your pet has renal, hepatic, or heart disease, diabetes mellitus, thyroid dysfunction, stomach ulcers, or any other medical condition. Inform your veterinarian if your pet is pregnant or lactating.

In doses larger than recommended, Fludrocortisone can reduce thymic activity and endogenous adrenal cortical or pituitary corticotrophin secretion. It also promotes the deposition of liver glycogen and can, without sufficient protein intake, cause negative nitrogen balance.

One large dose is not likely to produce symptoms of overdose. Overdose is most likely with prolonged use. Symptoms may include weight gain, fluid retention, edema, hypertension, Cushing's syndrome, and elevated blood potassium levels. Seek veterinary care.

Signs of an allergic reaction include facial swelling, hives, itching, rash, labored breathing, and seizures. Seek emergency veterinary treatment.

Do not administer any vaccine to a pet taking Fludrocortisone unless it is specifically approved by your veterinarian. Tell your veterinarian what drugs and supplements your pet takes before the prescription is written. Consult before administering any other drugs or supplements to a pet taking this medication.

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