Products 1-2 of 2
Diphenhydramine 25 mg, 100 Tablets
Retail: $6.99
Retail: $6.99
Price: $4.55 Save: $2.44

use coupon:

estimated: $ 4.55

Availability: Back Order
review-star review-star review-star review-star review-star
Availability: Back Order
Generic Mfr Item #: 1016660 -

Diphenhydramine 50 mg, 100 Tablets
Price: $10.07

use coupon:

estimated: $ 10.07

Availability: Back Order
Availability: Back Order
Generic Mfr Item #: 1016662 -

Diphenhydramine 50mg, 100 Tablets Product Description: Diphenhydramine is an antihistamine used in the treatment of allergies, insect bites or stings and other causes of itching. It is also used for its sedative and antiemetic effects in the treatment of motion sickness and travel anxiety. It is also used for its antitussive effect. Availability: Diphenhydramine is a non-prescription (OTC) product available as 25mg and 50mg tablets or capsules as well. How this medicine should be used:...

Antihistamines for Pets

Diphenhydramine is an antihistamine for dogs and cats that is used in the treatment of allergies, insect bites or stings, and itching. Diphenhydramine can also be used for its antiemetic effects.

Diphenhydramine treats itching, sneezing, stuffiness, coughing, and other symptoms associated with allergies, bug bites and stings, and other causes in cats and dogs. Along with its antihistamine properties, this product has a sedative effect that helps calm anxious pets and can function as a sleep aid. Diphenhydramine also has antiemetic action and helps remedy motion sickness.

Benefits of Diphenhydramine:

  • Antihistamine to treat seasonal allergies and allergic responses
  • Remedies the body's response to insect bites and stings
  • Soothes itching and other superficial irritations
  • Relieves sneezing, stuffiness, and coughing
  • Provides antiemetic effects to relieve motion sickness
  • Sedates pets to relieve travel and other anxiety
  • Helps pets sleep better
  • Available in time-release capsules for long-lasting relief
  • A variety of generics available at low cost

Read all label instructions and warnings before use.

Use Diphenhydramine as instructed by your veterinarian.


  1. Give cats and dogs 0.2 to 5 mg per pound of body weight every 8 to 12 hours as recommended by your veterinarian.
  2. Do not mix or dissolve the slow-release capsules in with food.

Frequency of Use:

Typical usage consists of administration 3 to 4 times per day.


Keep out of reach of children and animals.

Store Diphenhydramine in its original container, tightly sealed, at room temperature. Protect from moisture, heat, and light. Do not store in a bathroom.

Discard unused or expired tablets or capsules.

It is a violation of Federal Law to use this product in a manner inconsistent with its labeling.

Diphenhydramine blocks the effects of histamine in the body. Histamine is involved in the body's immune response to irritants such as allergens and bug bites and stings. Diphenhydramine is FDA-approved for use in cats and dogs externally only; however, oral tablets and capsules are commonly recommended by veterinarians for cats and dogs. 

Diphenhydramine Active Ingredient (per tablet or capsule): diphenhydramine 25 mg or 50 mg


Keep Diphenhydramine out of reach of children and animals. Do not use or store in or near open flame or heat.

Diphenhydramine is intended for use in cats and dogs. Do not give to other species or humans.

CAUTION: Do not concurrently give pets a cold, sinus, or other medication containing diphenhydramine.

Not for use in pregnant or nursing animals.

Not for use in any animal with hypertension, a urinary obstruction, glaucoma, or prostate disease.

Use with caution when given in conjunction with other central nervous system depressants.

Tell your veterinarian what other medications or supplements your pet takes. Always consult prior to administering any other drug or supplement to a pet taking Diphenhydramine.

Do not use in an animal with an allergy to diphenhydramine or other antihistamines. Seek emergency veterinary care for an allergic reaction.

Side effects may include decreased urinary output, drowsiness, dry mouth, and, rarely, diarrhea or vomiting.

An overdose requires immediate veterinary treatment. An overdose may cause extreme drowsiness, seizures, coma, respiratory depression, and death.

Customer ServiceFree Shipping

The VetDepot Difference