Dog Pheromone Anxiety Medication

D.A.P. or Dog Appeasing Pheromone is a pheromone produced by mother dogs with their puppies. Pet medications with D.A.P. calm dogs and offer natural ways to help dogs cope with stressful situations like moving, crating, or trips to the vet.

D.A.P., an acronym for dog-appeasing pheromone, comforts and calms anxious, nervous, and otherwise emotionally upset dogs. D.A.P. is available in an electric diffuser for continuous use in the home, a spray for use in your vehicle, on targeted areas, or in strange locations, and in small and large collars for use in and outside the home. These products help stop stress-related symptoms and behaviors, including excessive vocalization, scratching, urination, defecation, loss of appetite, loss of interest in playing, and others. They are ideal when there are unfamiliar animals or pets around your dog, during grooming, travel, or crating, when there are recurring loud noises such as those from fireworks, construction, or thunder, and any other time environmental factors are stressful for your pet.

Benefits of D.A.P.:

  • Stops stress-induced behavioral problems, including barking, whimpering, whining, scratching, urinating, and defecating
  • Alleviates symptoms of anxiety and other emotional upset, including diminished appetite and lack of interest in activity, play, and social interaction
  • Provides comfort when your dog is upset by strange people or animals, noises, travel, boarding, or other environmental changes
  • Works without medication, mimicking the effects of naturally-occurring pheromones from mother dogs
  • Odorless, does not stain, and does not affect humans or other animals
  • Available in 3 effective forms: collars, spray, and refillable electric diffuser
  • One diffuser vial lasts approximately 1 month and covers up to 750 sq. ft.
  • Spray works in about 15 minutes
  • Does not sedate or tranquilize

D.A.P. is only effective on dogs.

Not for internal use. Diffuser and spray are not for use directly on animals.

Review package directions and warnings.

Consult your veterinarian before using any D.A.P. product.

D.A.P. Refillable Electric Diffuser Directions:

  1. Remove vial cap.
  2. Screw diffuser onto vial securely.
  3. Plug diffuser into an electrical outlet in the room your dog spends the most time in.
  4. Replace vial with a refill every 4 to 6 weeks.

D.A.P. Spray Directions:

  1. 1.Shake bottle well.
  2. 2.Administer 8 to 10 sprays to car seat, bedding, crate, or other target location 15 minutes prior to desired effects.
  3. 3.Reapply every 2 hours as needed.

D.A.P. Small and Large Collar Directions:

  1. 1.Fasten collar around your dog's neck and adjust for appropriate fit.
  2. 2.Cut off overhang.
  3. 3.Remove collar before bathing and do not put it back on until coat is dry.
  4. 4.Replace collar every 4 weeks.

Frequency of Use:

D.A.P. diffuser vials last approximately 4 weeks. If any liquid is left after 6 weeks, replace anyway. Replace electric diffuser after 6 months/6 vials. D.A.P. spray's effects vary from dog to dog, but usually last 1 ½ to 2 hours; reapply every 2 hours as needed. D.A.P. collars remain effective for approximately 4 weeks.


Keep out of reach of children and animals.

Store at controlled room temperature.

It is a violation of Federal Law to use this product in a manner inconsistent with its labeling.

Mother dogs give off an appeasing pheromone to calm their pups. D.A.P. mimics this pheromone and its effects, providing comfort to dogs that are upset or afraid. This improves their mood and settles their anxious behaviors.

D.A.P. is sold over the counter.

D.A.P. (dog-appeasing pheromone)

  • D.A.P. Diffuser vials and refills: 48 mL
  • D.A.P. Spray: 60 mL bottles.
  • D.A.P. Collars for puppies and small dogs: One 17" Collar (Fits necks up to 15")
  • D.A.P. Collars for medium and large dogs: One 27" Collar (Fits necks up to 25")

D.A.P. Diffuser and Refill Ingredients: dog-appeasing pheromone 2%, excipients to 100 g

D.A.P. Spray Ingredients: dog-appeasing pheromone 2%, isopropanol filled to 60 mL

D.A.P. Large and Small Collar Ingredients: dog-appeasing pheromone 2.5%, inert ingredients 97.5%


Keep this product out of reach of children and animals. Flammable; do not use or store in or near open flame or heat.

D.A.P. is only effective on dogs.

Not for internal use. Spray and diffuser vials are not for use directly on pets.

Do not use collars on dogs with numerous skin lesions.

CAUTION: Do not consume or inhale. Keep away from eyes and skin. In the event of ocular contact, wash eyes thoroughly with water and contact a physician. Wash skin with water and soap; see a physician if irritation results. If swallowed, contact your doctor or a poison control center immediately with the packaging available.

Diffusers require adult assembly. Do not plug them in behind or underneath furniture. Do not cover. Use away from fabrics and other ignitable materials.

Use diffusers only in properly functioning 120-volt electrical outlets. Do not use adapters or electrical cords. Check that house voltage matches product requirements.

Do not touch diffusers once they are plugged in with metal or wet hands. Do not handle during use. Surface becomes hot.

Dispose of in accordance with local regulations regarding disposal of waste products.

Warranty and Manufacturer Information:

D.A.P. Refillable Electric Diffuser: NAC No.: 13280000

D.A.P. Spray: NAC No.: 13280020

D.A.P. Collars: NAC No.: 13280010

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