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Clomicalm 20 mg, Blue, 30 Tablets
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Novartis Animal Health Item #: 1010425 -
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Clomicalm 5 mg, 30 Tablets (Yellow)
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Novartis Animal Health Item #: 1017448 -
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Clomicalm 80 mg, Green, 30 Tablets
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Retail: $121.99
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Novartis Animal Health Item #: 1010427 -
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Separation Anxiety Medication

Clomicalm is a tricyclic antidepressant (clomipramine) that's used to treat separation anxiety in dogs as part of behavior modification plans. Clomicalm makes it easier for dogs to learn new, positive behaviors. By easing anxiety caused by separation, Clomicalm controls destructive behavior, vocalization, and other negative behaviors.

Clomicalm is a tricyclic antidepressant that effectively minimizes the symptoms of separation anxiety disorder in dogs when used in conjunction with a comprehensive behavior modification program. When used as prescribed, Clomicalm can control barking, moodiness, inappropriate defecation and urination, and other symptoms of separation anxiety.

Benefits of Clomicalm:

  • Controls negative behaviors without altering your dog's personality
  • Very effective when used in conjunction with behavior modification
  • Helps manage destructive behavior, vocalization, inappropriate elimination, excessive salivation, and other symptoms caused by anxiety
  • Side effects are generally mild when used as directed
  • Helps control obsessive-compulsive behavior
  • Does not affect memory
  • Works by altering your dog's brain chemicals, not by sedation

Use this medication as prescribed. Do not allow children to handle or administer Clomicalm. For use in dogs only.

Use of Clomicalm is not intended to replace behavioral modification; the medication is most effective when used along with a behavior modification program.

The recommended daily dose of Clomicalm is 0.9-1.8 mg/lb. Administer this medication as a single dose or as a divided dose given twice daily. Dividing the dose may reduce side effects.


  1. Hand-feed Clomicalm with a small amount of food to reduce vomiting.
  2. Give 5 mg daily to dogs weighing 2.75-5.5 lbs.
  3. Give 10 mg daily to dogs weighing 5.6-10.9 lbs.
  4. Give 20 mg daily to dogs weighing 11-22 lbs.
  5. Give 40 mg daily to dogs weighing 22.1-44 lbs.
  6. Give 80 mg daily to dogs weighing 44.1-88 lbs.
  7. Give 160 mg daily to dogs weighing 88.1-176 lbs.
  8. Reduce the dose under instruction by your veterinarian once symptoms are improved.

Frequency of Use:

Improvement in symptoms may not be evident for days or weeks. Do not stop using this medication unless told to do so by your veterinarian.

Do not use for longer than 12 weeks unless instructed to do so by your veterinarian. Withdrawal from Clomicalm should involve tapering the dose while monitoring the dog for behavioral changes and withdrawal symptoms.


Store Clomicalm at controlled room temperature, away from moisture, and in the original container. Keep away from pets and children.

It is a violation of Federal Law to use this product in a manner inconsistent with its labeling.

Clomicalm reduces symptoms of anxiety by affecting levels of serotonin and norepinephrine in the central nervous system of dogs. Although Clomicalm may cause some drowsiness and lethargy, this sedative effect is not responsible for the reduction in symptoms.

Clomicalm (clomipramine)

Clomicalm Tablets are available in strengths of 5 mg, 20 mg, 40 mg, and 80 mg. The tablets are contained in color-coded packaging.


Keep this product out of reach of children and animals. Do not use or store in or near open flame or heat.

Clomicalm is only for use in dogs 6 months or older. Do not give to other animals. Do not use in humans. Seek immediate medical attention for ingestion by humans, especially children. Overdose in humans causes convulsions, tachycardia, and arrhythmia.

CAUTION: Do not give Clomicalm to dogs with a known hypersensitivity to any tricyclic antidepressants. This medication is contraindicated for dogs with a history of seizures disorders. Do not use if your dog is currently being treated with medication that lowers the seizure threshold.

Do not use this medication in male breeding dogs.

Do not give to dogs currently undergoing treatment with a monoamine oxidase inhibitor (MAOI). Do not use within 14 days before or after treatment with an MAOI.

Use cautiously in dogs with urinary retention, increased intraocular pressure, narrow angle glaucoma, and reduced gastrointestinal motility. Consult your veterinarian before using in dogs with a history of liver disease.

It is not known if Clomicalm is safe for use in pregnant and lactating females.

Side effects of Clomicalm may include lethargy, emesis, diarrhea, constipation, reduced appetite, dry mouth, polydipsia, tremors, aggression, seizures, polyuria, anisocoria, and hyperthermia.

Warranty and Manufacturer Information:

Manufactured for: Novartis Animal Health US, Inc., Greensboro, NC 27408, USA

NADA # 141-120, Approved by FDA

©2008 Novartis Animal Health US, Inc.

Clomicalm is a registered trademark of Novartis AG.




NAC No.: 11310005

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