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Anipryl (selegiline) 10 mg, 30 Tablets
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Anipryl (selegiline) 15 mg, 30 Tablets
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Anipryl (selegiline) 30 mg, 30 Tablets
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Anipryl (selegiline) 5 mg, 30 Tablets
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Selegiline Cushing's Disease Pet Medications

Anipryl (selegiline) is a monoamine oxidase inhibitor (MAOI) prescription pet medication that's used to treat Cushing's Disease in dogs. Anipryl also treats dogs with behavioral changes due to aging and senility.

Anipryl is a monoamine oxidase inhibitor, or MAOI. It is used in dogs to treat Canine Cognitive Dysfunction Syndrome, or senility. Anipryl also helps control Cushing's disease in dogs resulting from a tumor on the pituitary gland.

Benefits of Anipryl:

  • First medication approved by the FDA for treating senility in dogs
  • First medication approved by the FDA for treating canine Cushing's Disease
  • Improves life for elderly dogs with age-related cognitive problems
  • Relieves symptoms associated with excess cortisol resulting from Cushing's Disease
  • Results in as little as one month in 70 percent of dogs treated for cognitive dysfunction
  • Results in as little as one month in dogs treated for Cushing's Disease
  • Easy once-daily oral dosing

Anipryl is only for dogs with senility or canine Cushing's Disease. Not for human use. Do not give to cats or other animals. Only for dogs with a prescription.

Keep out of reach of children. Do not allow children to administer or otherwise handle Anipryl. Read directions and precautionary statements before use.

The following directions represent a standard use. Use exactly as prescribed by your veterinarian.


  1. Remove only one dose from the blister pack. Return the remaining medication to its safe storage location.
  2. Give your dog a dose of 0.2-0.45 mg per pound of body weight in the morning when treating for canine cognitive dysfunction.
  3. Give your dog a dose of 0.45 per pound of body weight in the morning when treating for canine Cushing's Disease.
  4. Double the dose to 0.9 mg per pound if dogs with Cushing's disease show no results after 2 months of treatment.
  5. Observe your dog to ensure consumption of the full oral dose.

Your veterinarian will monitor your dog and may adjust the dosage until a proper dose is found. Your dog and the dosage will be reevaluated periodically. Dogs with Cushing's Disease that show no improvement after 1 month at the doubled dosage should be reevaluated.

Frequency of Use:

Anipryl is administered once a day, preferably in the morning.

If you miss a dose and it is more than 16 hours until the next day's scheduled dose, give your dog the tablet as soon as you remember. If you miss a dose and there is less than 16 hours until the next regularly scheduled dose, skip the dose and resume the normal schedule the next day. Never give a double dose of Anipryl.


Store in original container and out of reach of children and animals.

Store Anipryl at controlled room temperature, from 68-77 degrees F. Protect this product from heat and moisture.

It is a violation of Federal Law to use this product in a manner inconsistent with its labeling.

Selegiline, the active ingredient in Anipryl, is a monoamine oxidase inhibitor (MAOI). It boosts a dog's dopamine concentration, enhancing cognitive functions to combat the effects of senility. Anipryl treats canine Cushing's Disease by suppressing the pituitary gland to reduce cortisone.

Anipryl is available only by prescription from your veterinarian.

Anipryl is sold in packages containing one blister pack of 30 oral tablets. It is available in five dosages: 2 mg, 5 mg, 10 mg, 15 mg, and 30 mg.


Keep this product out of reach of children and animals. Do not use or store in or near open flame or heat.

Anipryl is intended for dogs with Canine Cognitive Dysfunction Syndrome or Cushing's Disease stemming from a pituitary gland tumor. Not for cats, other animals, or humans.

Do not give Anipryl to any dog that does not have a prescription for it.

Use only as directed by your veterinarian.

CAUTION: Side effects may include itching, diarrhea, vomiting, diminished appetite, drooling, sleep disturbances, dry mouth, anemia, lethargy, disorientation, impaired hearing, restlessness, mood changes, repetitive behaviors, uncontrollable movements, and shaking.

Talk to your veterinarian immediately if you observe any adverse reaction in your pet.

Not for animals with a hypersensitivity to selegiline. Some signs of an allergic reaction include facial swelling, sudden-onset diarrhea, vomiting, difficulty breathing, pale gums, hives, scratching, seizures, and coma. Seek emergency veterinary attention.

Mood swings, nervousness, inability to sleep, headache, dizziness, hallucinations, seizures, weakness, or perspiration are signs of an overdose. Take your pet for emergency veterinary care if you suspect or know of an overdose.

The safety of Anipryl in pregnant, nursing, and breeding dogs has not been determined.

Tell your veterinarian if your dog takes meperidine or fluoxetine. Consult your veterinarian before giving your pet any supplement or medication.

Warranty and Manufacturer Information:

For a copy of the Material Safety Data Sheet (MSDS) or to report adverse reactions call Pfizer Animal Health at 1-800-366-5288.

NADA #141-080, Approved by FDA

Manufactured by: DRAXIS Specialty Pharmaceuticals Inc., Kirkland, QC, Canada H9H 4J4

Distributed by: Pfizer Animal Health, Div. of Pfizer Inc, NY, NY 10017


July 2005

Made in Canada

NAC No.: 36900002