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Pet Tranquilizers

Acepromazine is a tranquilizer for dogs and cats with phenothiazine that is prescribed to treat anxiety from travel, grooming, and as preoperative anesthetic.

Acepromazine is a tranquilizer. It sedates pets for travel, grooming, and minor procedures. It is also beneficial when pets are fearful or anxious due to environmental factors such as thunderstorms, a houseful of company, or fireworks. Additionally, Acepromazine sedates pets prior to administration of anesthesia to reduce the anesthetic requirements.

Benefits of Acepromazine:

  • Sedates pets when they are upset
  • Sedates animals for some examinations, including X-rays
  • Sedates pets for minor veterinary procedures and pre-anesthesia
  • Facilitates travel and nail clipping and other grooming procedures
  • Oral tablets for cats and dogs, and an injectable form for horses (and sometimes cats and dogs)
  • Tablets available in two strengths for dosing convenience
  • Helps prevent vomiting due to motion sickness or post-surgery
  • Injectable form relieves itchiness from irritated skin
  • Fast-acting calming effect
  • Low-cost generic products

Acepromazine tablets are only for cats and dogs. Acepromazine injectable solution is only for horses, cats, and dogs. Do not use this product in any animal to which it was not prescribed. Do not administer to other animals. Do not use in humans.

Children should never be permitted to administer any tranquilizer or sedative to an animal.

Read all instructions and warnings provided by the manufacturer.

The following directions represent a standard use. However, various factors affect usage. Administer exactly as prescribed by your veterinarian.

Acepromazine Tablet Directions:

  1. Administer 0.25 to 1 mg per pound of body weight orally.
  2. Give dose 45 minutes to 1 hour prior to procedures or needed effects.

Acepromazine Injection Directions:

  1. Restrain animal as needed.
  2. Sterilize needle and site of injection.
  3. Administer 0.25 to 0.5 mg per pound of body weight to dogs.
  4. Administer 0.5 to 1 mg per pound of body weight to cats.
  5. Administer 2 to 4 mg per 100 lbs. of body weight to horses.
  6. Inject subcutaneously or intramuscularly. Intravenous injection must be given slowly.
  7. Give dose at least 15 minutes prior to procedures or needed effects.


Keep out of reach of children and animals.

Store at room temperature, between 59 and 86 degrees F. Keep in original container, tightly sealed, away from heat and moisture.

It is a violation of Federal Law to use this product in a manner inconsistent with its labeling.


Keep this product out of reach of children and animals. Do not use or store in or near open flame or heat.

Acepromazine tablets are only for cats and dogs. Acepromazine injectable solution is only for cats, dogs, and horses. Not for use in other animals or in any animal that does not have a prescription. Not for use in humans.

Use as prescribed by your veterinarian.

CAUTION: Do not administer Acepromazine to any animal intended for human consumption.

Use with caution in animals with a history of liver dysfunction or leukopenia.

Acepromazine tablets may rarely cause very mild, brief respiratory distress.

Some irritation may occur at site of injection. Monitor for signs of infection and consult your veterinarian should you notice any.

Do not use Acepromazine to control tremors resulting from organic phosphate poisoning.

Do not use concurrently with organophosphorus vermifuges, ectoparasiticides (including flea collars), or procaine hydrochloride.

Acepromazine is a potent central nervous system depressant that causes sedation.

As with most tranquilizers, this product may cause prolonged depression or motor restlessness in high doses or in sensitive animals.

Acepromazine strengthens the action of other depressants and general anesthesia.

Phenothiazine tranquilizers like Acepromazine may potentiate the arterial hypotensive effects of local anesthetics.

In rare instances, dogs may bite, chew, or experience nervousness or aggression in response to this product. Do not use Acepromazine to treat aggression.

As with other phenothiazine-derived tranquilizers, injection of this product may result in paralysis of the retractor penis muscle in horses. To reduce risk, administer as low a dose as possible for the desired effect. Injection can be expected to produce protrusion of the penis, and it is not possible to differentiate right away between a normal transient reaction and an irreversible reaction. The cause of this side effect remains unknown, but it has been postulated that it occurs when tranquilizers are used concurrently with testosterone.

Intracarotid injection may result in disorientation, convulsive seizures, death, or other adverse reactions.

Hypotension and cardiovascular collapse can result from rapid intravenous administration of the injectable form of this tranquilizer.

Do not use epinephrine to treat hypotension resulting from administration of phenothiazine tranquilizers such as this one, as it can result in further reduction of blood pressure.

Seek emergency veterinary treatment for an overdose. Signs may include excessive drowsiness, slow breathing or heart rate, seizures, loss of consciousness, hypotension, or unsteady movements.

Seek emergency veterinary attention for an allergic reaction. Signs may include facial swelling, seizures, hives, itching, rash, or difficulty breathing.

Tell your veterinarian if your pet takes any supplements or drugs. Consult before administering any supplements or drugs to an animal taking Acepromazine.

Warranty and Manufacturer Information:

Distributed by: VEDCO, INC., St. Joseph, MO 64507

Acepromazine Tablets: NAC No.: 10940022

Acepromazine Injectable Solution: NAC No.:10940012

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