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Broad-Spectrum Antibiotics for Pets

SMZ-TMP (sulfamethoxazole and trimethoprim) is a broad-spectrum antibiotic for cats and dogs. SMZ-TMP is used to treat a variety of bacterial and protozoal infections, including diarrhea, many urinary and respiratory tract, gastrointestinal, skin, and ear infections. Although SMZ-TMP is not FDA-approved for use in animals, it is common practice for veterinarians to prescribe it in cats and dogs.

SMZ-TMP is an antibiotic that treats a variety of urinary tract, respiratory, gastrointestinal, ear, and skin infections. It works on an array of bacterial and protozoal infections. This effective broad-spectrum anti-infective agent is easily administered to cats and dogs once or sometimes twice per day.

Benefits of SMZ-TMP:

  • Effective against a number of bacteria and protozoa
  • Works on many skin, GI, respiratory, ear, and urinary tract infections
  • Remedies certain types of diarrhea
  • Synergistic action provided by two active ingredients, sulfamethoxazole and trimethoprim
  • Easy administration, usually only once daily
  • Scored tablets available in regular and double strength
  • Low-cost generic medication

SMZ-TMP is for use in cats and dogs. Do not administer to other animals. Do not use in humans.

Children should not be permitted to give this medication to a pet.

Read all manufacturer instructions and precautionary statements for safe and effective use.

Do not cease administration early because symptoms have cleared up; this may occur before the infection is fully treated.

The directions below represent a standard regimen. Follow the specifications of your veterinarian's prescription.


  1. Administer 13 mg per pound of body weight once per day.
  2. Alternatively, administer 6.5 mg per pound of body weight every 12 hours, or as your veterinarian prescribes.
  3. Hand-feed tablets directly or crush them and add them to food.
  4. Give with food.
  5. Allow your pet plenty of water and encourage drinking.

Frequency of Use:

SMZ-TMP is given once or twice per day.

Give a missed dose as soon as you remember it. However, if it is almost time for the next dose, just wait and resume the normal schedule then. Do not give a double dose of this medication.


Keep out of reach of children and animals.

Store this antibiotic at room temperature. Protect product from moisture and heat.

It is a violation of Federal Law to use this product in a manner inconsistent with its labeling.

SMZ-TMP provides a synergistic blend of sulfamethoxazole and trimethoprim. Trimethoprim enhances the effectiveness of sulfamethoxazole. This antibiotic works by inhibiting the synthesis of folic acid in bacteria, preventing their production of proteins essential for life and reproduction.


Keep this product out of reach of children and animals. Do not use or store in or near open flame or heat.

SMZ-TMP (sulfamethoxazole and trimethoprim) is for use in cats and dogs. Do not use in other animals or humans. Only give this medication to the animal to which it was prescribed.

Use exactly as prescribed.

Encourage your pet to drink plenty of water during treatment.

CAUTION: Tell your veterinarian if your pet has urinary tract stones, liver or kidney disease, or a glucose-6-phosphate dehydrogenase deficiency.

Not for use in pregnant or nursing animals.

Not for use in animals allergic to this medication or other sulfa drugs. Seek emergency veterinary treatment for an allergic reaction.

Use with caution in animals with anemia or other blood cell irregularities.

SMZ-TMP may increase your pet's sensitivity to sunlight.

Sulfa crystals in the urine is a common side effect. This is not cause for concern as long as your pet remains well hydrated. Fatigue, dizziness, nausea, vomiting, diarrhea, dry eyes, diminished appetite, or other minor side effects may occur. Mention them to your veterinarian.

More serious side effects include unusual bruising or bleeding, jaundice, ocular discharge, eye redness, squinting, anemia, fever, joint inflammation, and kidney damage. Discontinue use and consult your veterinarian right away if you notice any of these adverse reactions.

If you suspect or know of an overdose, seek veterinary care immediately. Signs may include nausea, vomiting, diarrhea, diminished appetite, decreased urine output, blood in the urine, jaundice, or coma.

Tell your veterinarian if your pet takes aspirin, warfarin, glipizide, or phenytoin. SMZ-TMP may interact with these and other drugs or supplements. Consult your veterinarian before administering anything to your pet concurrently with this antibiotic.

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SMZ-TMP 480 mg, 100 Tablets
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