Effipro Topical Solution for Cats, 12 Month is a topical product designed for fast-acting and effective flea and tick control. The fipronil in Effipro flea treatments kills fleas, ticks (including those that spread Lyme disease), mosquitoes, and lice. Only one application of Effipro is able to control fleas for up to 6 weeks and ticks for up to 4 weeks.