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Tetracycline
Trade
and Other Names
Panmycin,
Duramycin powder
Drug
Class
Antibacterial
Mechanism of Action and Clinical Use
Tetracycline antibiotic. Mechanism of action of
tetrecyclines is to bind to 30S ribosomal subunit and
inhibit protein synthesis. Usually bacteriostatic, with
broad-spectrum activity, including bacteria, some protozoa,
Rickettsia spp. Used to treat a variety of infections,
including pneumonia and urinary tract infection.
Adverse Effects
Tetracyclines in general may cause tubular nucrosis at high
doses. Tetracyclines can affect bone and teeth formation in
young animals. Tetracyclines have been implicated in drug
fever in cats. Hepatotoxicity may occur at high doses in
susceptible individuals.
Contraindications, Precautions, and Drug Interactions
Do not
use in young animals; it can affect bone and teeth
formation. Drug interactions: Tetracyclines bind to
calcium-containing compounds, which decreases oral
absorbtion.
Instructions for Use
Pharmacokinetic and experimental studies have been conducted
in small animals, but there have been no clinical studies.
Do not use outdated solutions. Use of tetracyclines has been
replaced primarily by doxycycline.
Small
Animal Dosage Information
(To
convert pounds to kilograms: Divide lbs by 2.2. For the
proper dosage, then multiply the mg/kg by the weight kg)
Dogs and
Cats: 15-20 mg/kg,q8h,PO; or 4.4-11 mg/kg,q8h,IV,IM
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