Tetracycline Trade and Other Names Panmycin, Duramycin powder Drug Class Antibacterial Mechanism of Action and Clinical Use Tetracycline antibiotic. Mechanism of action of tetrecyclines is to bind to 30S ribosomal subunit and inhibit protein synthesis. Usually bacteriostatic, with broad-spectrum activity, including bacteria, some protozoa, Rickettsia spp. Used to treat a variety of infections, including pneumonia and urinary tract infection. Adverse Effects Tetracyclines in general may cause tubular nucrosis at high doses. Tetracyclines can affect bone and teeth formation in young animals. Tetracyclines have been implicated in drug fever in cats. Hepatotoxicity may occur at high doses in susceptible individuals. Contraindications, Precautions, and Drug Interactions Do not use in young animals; it can affect bone and teeth formation. Drug interactions: Tetracyclines bind to calcium-containing compounds, which decreases oral absorbtion. Instructions for Use Pharmacokinetic and experimental studies have been conducted in small animals, but there have been no clinical studies. Do not use outdated solutions. Use of tetracyclines has been replaced primarily by doxycycline. Small Animal Dosage Information (To convert pounds to kilograms: Divide lbs by 2.2. For the proper dosage, then multiply the mg/kg by the weight kg) Dogs and Cats: 15-20 mg/kg,q8h,PO; or 4.4-11 mg/kg,q8h,IV,IM