Bio Case V Capsules
Digestive Aid & Replacement Therapy
A digestive pancreatic intestinal aid used in replacement therapy where
digestion of protein, carbohydrate and fat is inadequate. Contains a pancreatic
enzyme concentrate of porcine origin.
DESCRIPTION
Bio Case-V is activated whole raw pancreas; a
pancreatic enzyme concentrate of porcine origin containing standardized amylase,
protease and lipase activities plus esterases, peptidases, nucleases and
elastase.
BACKGROUND INFORMATION
A review of the literature over the past 20
years, together with clinical experience, prompts the conclusion that
pancreatitis is an important disease in the dog. Evidence of the disease was
observed in approximately 3% of a series of dogs necropsied at the Angell
Memorial Animal Hospital. Others have classified disease of the pancreas into 4
distinctive categories: acute necrotic pancreatitis; subacute or chronic
pancreatitis; pancreatic fibrosis; and collapse or atrophy of the acinar
pancreatic tissue. Only acute and chronic pancreatitis is readily recognized
clinically.
Dogs that acquire acute pancreatitis usually
recover, but are subject to exacerbations of the chronic inflammatory process
that may persist. Complete healing of the acute lesion may not occur, and
progressive destruction of the gland may take place over a period of months,
even in the absence of clinical signs.
Chronic pancreatitis is characterized by acute
exacerbations of pancreatic inflammation that occur after the remission of acute
pancreatitis. Signs of the disease are similar to those of acute pancreatitis
but are usually less severe.
Steatorrhea, diarrhea, weight loss and
increased appetite characterize the digestive impairment caused by failure of
pancreatic exocrine secretion. Secretion ceases when the acinar tissue is
destroyed in the course of chronic pancreatitis. This sequela does not become
evident until virtually total destruction of the acinar pancreas has occurred,
because as little as 12 to 20 percent of the exocrine pancreas can secrete
enough pancreatic juice to sustain digestion. Thus, digestive impairment is a
relatively late event in the pathogenesis of chronic pancreatitis. Transient
episodes of fetid diarrhea may occur at the time of an acute exacerbation, and
may be caused by a temporary reduction of pancreatic exocrine secretion.
However, food engorgement or the ingestion of fatty food often precipitates an
exacerbation of chronic pancreatitis and the character of the food, rather than
the absence of pancreatic enzymes, may cause the diarrhea.
The veterinarian should not be too concerned
about whether the pancreatic lesion is acute or chronic. Their primary concern
should be to recognize pancreatic inflammatory disease and begin treatment. The
differentiation of acute and chronic pancreatitis is then made on the basis of
history, and is of importance in advancing a prognosis.
INDICATIONS
As a digestive aid; replacement therapy where
digestion of protein, carbohydrate and fat is inadequate due to exocrine
pancreatic insufficiency.
PRECAUTIONS
Discontinue use in animals with symptoms of
sensitivity.
TREATMENT IN ACUTE AND CHRONIC PANCREATITIS
The most important aspect of the treatment of
acute pancreatitis is initiation of vigorous therapy aimed at combating pain and
shock, restoring blood volume, blood pressure and renal function, with reducing
pancreatic secretions and combating secondary infection of necrotic tissue.
Animals surviving an acute attack should be placed on a bland and easily
digested diet (such as Prescription Diet®, i/d) and supplemented with
Bio Case-V.
In chronic pancreatitis, replacement therapy
must be given for the duration of the animal's life. Three daily feedings of a
bland and easily digested diet containing sufficient quantities of good quality
proteins and carbohydrates and low levels of fat are recommended (i.e.,
Prescription Diet, i/d). Bio-Case-V is given with each meal at a dosage level
sufficient to keep the feces normal.
ADMINISTRATION AND DOSAGE
The Bio Case-V capsules are administered before
each meal. Bio Case-V powder is added to moistened dog food (canned or dry).
Thorough mixing is necessary to bring the enzymes into close contact with the
food particles. Incubation at room temperature for 15-20 minutes before feeding
appears to enhance the digestive process. Frequent feeding, at least 3 times
daily, is important.
USUAL DOSAGE
Dogs: 2-3 tablets or ¾-1 teaspoonful (2.8
g/teaspoonful) with each meal.
Cats: ½-1 tablet or ¼-¾ teaspoonful (2.8
g/teaspoonful) with each meal.
NOTE: No one regimen will be successful for
every patient. The above dosage should be adjusted according to the severity of
the pancreatic exocrine deficiency and weight of the animal. In cases of chronic
insufficiency, the dosage should be increased until desired results are
obtained.
Each capsule contains sufficient pancreatic
enzymes to digest (in vitro):
33 g fat
57 g protein
64 g starch.
Each capsule contains:
|
Lipase |
9,000 USP units |
|
Protease |
57,000 USP units |
|
Amylase |
64,000 USP units |