As in humans, your pet's liver is one of the largest organs in its body and it performs many life essential functions.  It also produces a range of hormones, enzymes, proteins, and other substances important for your pet's health and life.  The liver also detoxifies and removes waste from the bloodstream by changing them into substances that can be eliminated.  This waste filtering is important because the toxins can damage the membranes of cells in the liver and other organs.  The most important “detoxifier” is glutathione, a strong antioxidant that protects liver cells (hepatocytes) from deterioration.  Denosyl SD4 protects liver cells from dying and is helpful in cell repair and healing.  Denosyl SD4 elevates liver glutathione, the liver's main detoxifier, as well as supports overall liver health.

Denosyl SD4 (S-adenosylmethionine) is a nutritional supplement for use to aid in managing a variety of liver problems in dogs and cats.  Denosyl SD4 may be used as an adjunct therapy for dogs and cats with elevated liver enzymes and suffering from: hepatic lipidosis, breed-specific chronic hepatitis, feline liver disease, Cushing's Disease, Inflammatory Bowel Disease, Pancreatitis, etc.  Denosyl SD4 is a pure, patented, uniform, bioavailable, and stable salt of S-Adenosylmethionine. 

Denosyl SD4 has been shown to increase hepatic glutathione levels in cats and dogs.  Glutathione, a potent antioxidant, is the liver's main detoxifier that protects hepatic cells from toxins and death.  A recent analysis of 31 dogs and cats with various severe liver problems showed that 45% of these animals had low hepatic glutathione levels.  Denosyl SD4 is recommended to improve hepatic glutathione levels in compromised patients to help maintain and protect liver function. Denosyl SD4 may also be used in other conditions of tissue oxidant injury and RBC fragility caused by certain toxins or drugs which are related to reduced glutathione concentrations.

Administration as a Dietary Supplement: The chart below is provided as a guide for administration. Daily dosage may also be calculated, based on 18 mg/kg of body weight and rounded to the closest tablet size or combination of sizes.

For optimal absorption, tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine.  When giving more than one tablet, the total daily dose may be provided as a morning and evening dose.  For example, a daily dose of three tablets could be divided into two tablets in the morning and one tablet in the evening.  Because the tablet must be kept intact to prevent destruction by stomach acid, administration utilizes a dosage range, based on the nearest whole-tablet dose.